A Milk Product Supplemented with a Herbal Extract for the Prevention of Osteoporosis: Justifications and Clinical Trial
International Journal of Nutrition and Food Sciences
Volume 4, Issue 2, March 2015, Pages: 184-188
Received: Feb. 5, 2015;
Accepted: Mar. 7, 2015;
Published: Mar. 12, 2015
Views 3079 Downloads 217
Ping-Chung Leung, Institute of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, the Chinese University of Hong Kong, Hong Kong, China
William King-Fai Cheng, Institute of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong, China
Winnie Wing-Man Lo, Institute of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong, China
Erik Chun-Hay Ko, Institute of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong, China
Sammy Wing-Sum Siu, Institute of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong, China
When osteoporosis presents as a disease, effective, quick therapeutic remedy is required. Potent effective pharmaceuticals are available. When osteoporosis is only a threat, prevention and not treatment should be a logical better choice. While the past two decades might have followed a radical treatment direction and adverse effects of potent bisphosphonates have started to appear, it is appropriate to explore effective means of using nutritional supplements specific for the maintenance of bone health when only active prevention is required. Traditional Chinese medicine works on the principle of physiological balance. One classical herb Fructus Ligustri Lucidi (FLL) has been studied in the laboratory for its bone protection effects which are found very positive. FLL is added to milk powder for daily consumption in a proper evidence-based clinical trial with a placebo group. The results showed that 39 women with post-menopausal period of 8.5±3.5 years, achieved an average increase of 0.97% in the spine bone mineral density (BMD) and a 1.47% increase in the hip score. No increase in body weight was found. It is therefore suggested that FLL could be a suitable bone health supplement in the prevention of osteoporosis.
William King-Fai Cheng,
Winnie Wing-Man Lo,
Erik Chun-Hay Ko,
Sammy Wing-Sum Siu,
A Milk Product Supplemented with a Herbal Extract for the Prevention of Osteoporosis: Justifications and Clinical Trial, International Journal of Nutrition and Food Sciences.
Vol. 4, No. 2,
2015, pp. 184-188.
E.M.C. Lau and P. C. Leung, The size of the problem, in Management of fractures in severely osteoporotic bone, K. Obrant, Eds. London: Springer Verlag, 2000, pp. 3-12.
National Institutes of Health, USA. NIH consensus statement on osteoporosis prevention, diagnosis and therapy. http://consensus.nih.gov/2000/2000osteoporosis111html.htm.
M. Roland M and R. Morris. A study of the natural history of low-back pain. Part II: development of guidelines for trials of treatment in primary care. Spine. 1983; 8: 145-150.
A. Papaioannou, C.C. Kennedy, G. Ioannidis, J. P. Brown, A. Pathak, D.A. Hanley, et al. Determinants of health related quality of life in women with vertebral fracture. Osteoporosis Int. 2006; 17: 355-363.
A. Cranney, V. Welch, G. Wells, J. Adachi, B. Shea, L. Simon L, et al. Discrimination of changes in osteoporosis outcomes. J Rheumatol. 2001; 28: 413-421.
D. M. Black, P. D. Delmas, R. Eastell, I. R. Reid, S. Boonen, J. A. Cauley, et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007; 356: 1909- 1922.
R. Eastell, D. B. Black, S. Boonen, S. Adami, D. Felsenberg, et al. Effect of once-yearly zoledronic acid on fracture risk and change in femoral neck bone mineral density. J Clin Endocrinol Metab. 2009, 94: 3215-3225.
B. M. Tang, G. D. Eslick, C. Nowson, C. Smith, A. Bensoussan. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007; 370:657–66.
Southern California Evidence-based Practice Centre. Vitamin D and calcium: A systemic review of health outcome. Natural Institutes of Health, Evidence Report No.217, 2014.
Chinese Pharmacopeia. Committee on Chinese Pharmacopeia Beijing: Chemical Industry Press. 2010, pp.31.
P. C. Leung, C. H. Ko, S. W. S. Siu, E. S. Y. Pang, E. L. Y. Wong, K. F. Cheng. Developing an Effective Health Supplement for the Prevention of Osteoporosis. Int. J Osteoprosis Metab Disorders 2012; 5(1): 1-12.
Y. Zhang, M. S. Wong, B. Chen, P. C. Leung, C. F. Wu, X. S. Yao. Effect of Fructus Ligustri Lucidi on calcium metabolism and vitamin D-dependent gene expressions in ovariectomized rats. Chin Tra Herb Drugs 2006; 37: 558-561.
Y. Zhang, W. P. Lai, P. C. Leung, C. F. Wu, X. S. Yao, M. S. Wong. Effects of Fructus Ligustri Lucidi extract on bone turn-over and calcium balance in ovariectomized rats. Biol Pharm Bull 2006; 29: 291-296.
Y. Zhang, X. L. Dong, P. C. Leung, C. T. Che, M. S. Wong. Fructus ligustri lucidi extract improves calcium balance and modulates the calciotropic hormone level and vitamin D-dependent gene expression in aged ovariectomized rats. Memopause 2008; 15: 558-565.
M. Cheng, Q. W. Wang, X. Y. Liu, Y. Z. Deng, C. Jia. Treatment with Fructus ligustri lucidi for osteoporosis in ovariectomised rats. China Pharmacological Bulletin 2013; 29: 229-233.
Y. Zhang, W. P. Lai, H. K. Chow, C. F. Wu, M. S. Wong. Short-term effect of dietary calcium deficiency on the biomechanical properties of femur in ovariectomized rats. Chin J Osteoporos 2006; 12: 253-257.
C. H. Ko, W. S. Siu, P. C. Leung. Anti-osteoporotic effects of a Chinese herbal formula ELP in a tail-suspension rat model. Proceedings 13th SCBA International Symposium Bioscience, Sun-Yat Sen University. Guangzhou, China. 2011.
Natural Institutes of Health. Glucosamine and chondroitin for osteoarthritis: What you need to know. NICAM, NIH, US Department of Health Public Access 2011.
A. S.Neviaser, J. M. Lane JM, B. A. Lenart, F. Edobor-Osula, D. G. Lorich. Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma. 2008, 22(5): 346-50.
American Dental Association. Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: Executive summary of recommendations from the American Dental Association Council on Scientific Affairs. JADA 2011; 142(11): 1243-1251.
Y. Zhang Y, T. Y. Diao, L. Wang, C. T. Che CT, M. S. Wong. Protective effects of water fraction of Fructus Ligustri Lucidi extract against hypercalciuria and trabecular bone deterioration in experimentally type 1 diabetic mice. J Ethnopharmacol. 2014; 158: 239-245.