Perspective Summary of Brief Report on Thyroid Disease of Post Glaciations Quaternary Is Endocrinology of Ecology System in Centre Marc Sankale Setting in Dakar
Clinical Medicine Research
Volume 9, Issue 3, May 2020, Pages: 59-64
Received: Apr. 6, 2020; Accepted: May 8, 2020; Published: Jun. 8, 2020
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Authors
El Hassane Sidibe, Centre de Clinique Medicale Marc Sankale [Hopital Abass N’Dao] Fellow du Collège de Médecine de Paris [Inside Salk.edu] RCL Guillemin Chair, Dakar, Senegal
Therese Moreira-Diop, Faculte de Medecine Pharmacie & Odontologie [UCAD], Dakar, Senegal
Jean-Francois Bach, Laboratoire d’Immunologie Clinique [Hopital Necker Enfants Malades], Paris, France
Baye Assane Diagne, Faculte de Medecine Pharmacie & Odontologie [UCAD], Dakar, Senegal
Francis Klotz, Hopital Val de Grace [Instruction des Armees], Paris, France
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Abstract
Reflexions about immunoradiometric Tsh and Trh test during on Optimal thyroid hormonal therapy (Optimal dosages and overdosages) as Pionnary Auto-immune Primary Hypothyroidism in Dakar [Senegal] gives us A Propose of Whitaker Syndrome Case Report and THYROID GLAND AND ITS PEPTIDES OR ACTUALITYOF GENERAL ENDOCRINOLOGY. Many peptides by their cell molecular metabolism in the thyroid gland are involved: mutations of TSH receptor is linked to hormone resistance with congenital hypothyroidism; a new oroxigenic peptide, Ghrelin is widespread in endocrine tissues; tachykinine is another novel peptide with endocrine paracrine effect. PTTG and FGF-2 are prognostic markers of differentiated cancers; CRIF1 is a novel protein of nucleus interacting with Gadd45 and could negatively regulate cycle cell progression and cell growth; mutations of RET protooncogene is now the best CMT biomarker in the place of calcitonin in addition with CGRP, CGRPβ and Amylin; regulating proteins of CAMP, protein G, Gi alpha 1, MAL proteolipid are identified near immunologic antigens involved in Grave’s disease, autoimmune polyendocrinopathies. These peptides by their diversity of function support the concept of general endocrinology equivalent of medical sciences. Bastenie P. A. classification is a bio-clinical semeiology that could be reviewed by doing the integration of obesity as the incipient stage of epigenetic thyroid turnover of deiodinase realizing an inactive TSH. Thus primary hypothyroidism in an historical-technically point of view can recognize since Bastenie: -1 Atrophic thyroid myxedema with: low T4 and low T3 and High TSH and TRH positive. -2 Mild hypothyroidism where only TSH is High and TRH Test positive. -3 Infra-clinic hypothyroidism where only TRH Test is positive. -4 Compensated thyroiditis where only auto-antibodies are positive. -5 Common obesity where deiodinase turnover is only disturbed. Iodine regulates nutritional metabolism probably via the microbiome. Thyro-diabetes has concerned clinicians. Endocrine disruptors have come to recall us if necessary that thyroid gland is a gate keeper of the environment which in our approach is the testimony of primordial role of mineral iodine in the majority of living beings. Here are the perspectives of General Practitioner of Endocrine Diseases and Clinical Medicine Department.
Keywords
Multicentric Epidemiology, Primary Hypothyroidism AutoImmunity, Diabetes, Africa Medical Sciences, Peptides Immunoradiometry, Thyreoliberine, Levothyroxine
To cite this article
El Hassane Sidibe, Therese Moreira-Diop, Jean-Francois Bach, Baye Assane Diagne, Francis Klotz, Perspective Summary of Brief Report on Thyroid Disease of Post Glaciations Quaternary Is Endocrinology of Ecology System in Centre Marc Sankale Setting in Dakar, Clinical Medicine Research. Vol. 9, No. 3, 2020, pp. 59-64. doi: 10.11648/j.cmr.20200903.13
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Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Y. I. TOURE, E. H. SIDIBE, M. L. DIOUF, B. A. DIAGNE, B. DIOP. (1988) Hypercalcémie, acidose tubulaire rénale, ulcère du bulbe duodénal et lithiases vésiculo-urinaires chez un hypothyroïdien. Sem. Hôp. Paris, 64, 2: 125-127.
[2]
Linda Humbert, Marjorie Cornu, Emmanuelle Proust-Lemoine, Jagadeesh Bayry, Jean-Louis Wemeau, Marie-Christine Vantyghem, Boualem Sendid (2018) Chronic Mucocutaneous Candidiasis in Autoimmune Polyendocrine Syndrome Type 1 Front Immunol.; 9: 2570.
[3]
Eystein S. Husebye, Mark S. Anderson, Olle Kämpe (2018) Autoimmune Polyendocrine Syndromes N Engl J Med.; 378 (12): 1132–1141.
[4]
Hargovind L Trivedi, Umang G Thakkar, Aruna V Vanikar, Shruti D Dave (2011) Treatment of polyglandular autoimmune syndrome type 3 using co-transplantation of insulin-secreting mesenchymal stem cells and haematopoietic stem cells BMJ Case Rep.; 2011: bcr0720114436.
[5]
C Betterle, F Lazzarotto, F Presotto (2004) Autoimmune polyglandular syndrome Type 2: the tip of an iceberg? Clin Exp Immunol.; 137 (2): 225–233.
[6]
Øyvind Bruserud, Bergithe E. Oftedal, Nils Landegren, Martina M. Erichsen, Eirik Bratland, Kari Lima, Anders P. Jørgensen, Anne G. Myhre, Johan Svartberg, Kristian J. Fougner, Åsne Bakke, Bjørn G. Nedrebø, Bjarne Mella, Lars Breivik, Marte K. Viken, Per M. Knappskog, Mihaela C. Marthinussen, Kristian Løvås, Olle Kämpe, Anette B. Wolff, Eystein S. Husebye (2016) A Longitudinal Follow-up of Autoimmune Polyendocrine Syndrome Type 1 J Clin Endocrinol Metab.; 101 (8): 2975–2983.
[7]
M. I. Drury, Deborah M. Keelan, F. J. Timoney, W. J. Irvine (1970) Juvenile familial endocrinopathy Clin Exp Immunol.; 7 (1): 125–132.
[8]
W. J. Irvine, A. G. Stewart, Laura Scarth (1967) A clinical and immunological study of adrenocortical insufficiency (Addison's disease) Clin Exp Immunol.; 2 (1): 31–70.
[9]
Sakeen W. Kashem, Bryce A. Binstadt (2017) Pathogenic and Protective Autoantibodies in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) Antibodies (Basel); 6 (1): 1.
[10]
R. Duclaux-Loras, F. Charbit-Henrion, B. Neven, J. Nowak, S. Collardeau-Frachon, C. Malcus, P. F. Ray, D. Moshous, J. Beltrand, O. Goulet, N. Cerf-Bensussan, A. Lachaux, F. Rieux-Laucat, F. M. Ruemmele (2018) Clinical Heterogeneity of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A French Multicenter Retrospective Study Clin Transl Gastroenterol.; 9 (10): 201.
[11]
Carmine Siniscalchi, Valentina Moretti, Simona Cataldo, Anna Rocci, Manuela Basaglia, Maria Ilaria Tassoni, Roberto Quintavalla, Carmine Siniscalchi, Valentina Moretti, Simona Cataldo, Anna Rocci, Manuela Basaglia, Maria Ilaria Tassoni, Roberto Quintavalla (2017) The Schmidt syndrome Acta Biomed.; 88 (4): 499–501.
[12]
Oleksander Prylutskyi, Olga Prylutska, Anatoliy Degonskyi, Kseniia Tkachenko (2016) A Case of Autoimmune Polyglandular Syndrome. ype 2 Associated with Atypical Form of Scleromyxedema Ethiop J Health Sci.; 26 (5): 503–507.
[13]
Gulbu Uzel, Elizabeth P. Sampaio, Monica G. Lawrence, Amy P. Hsu, Mary Hackett, Morna J. Dorsey, Richard J. Noel, James W. Verbsky, Alexandra F. Freeman, Erin Janssen, Francisco A. Bonilla, Joseph Pechacek, Prabha Chandrasekaran, Sarah K. Browne, Anahita Agharahimi, Ahmed M. Gharib, Sara C. Mannurita, Jae Joon Yim, Eleonora Gambineri, Troy Torgerson, Dat Q. Tran, Joshua D. Milner, Steven M. Holland (2013) Dominant gain-of-function STAT1 mutations in FOXP3WT IPEX-like Syndrome J Allergy Clin Immunol.; 131 (6): 1611–1623.e3.
[14]
M Hong, K R Ryan, P D Arkwright, A R Gennery, C Costigan, M Dominguez, D W Denning, V McConnell, A J Cant, M Abinun, G P Spickett, D C Swan, C S Gillespie, D A Young, D Lilic (2009) Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy Clin Exp Immunol.; 156 (1): 40–51.
[15]
T. Petteri Arstila, Hanna Jarva {2013) Human APECED; a Sick Thymus Syndrome? Front Immunol.; 4: 313.
[16]
Shrinivas Bishu, Violeta Arsenescu, Eun Y Lee, H David Vargas, Willem JS de Villiers, Razvan Arsenescu (2011) Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel intraepithelial lymphocytosis: case report and literature review BMC Gastroenterol.; 11: 131.
[17]
Dong Li, Elizabeth A. Streeten, Alice Chan, Wint Lwin, Lifeng Tian, Renata Pellegrino da Silva, Cecilia E. Kim, Mark S. Anderson, Hakon Hakonarson, Michael A. Levine (2017) Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism J Clin Endocrinol Metab.; 102 (5): 1726–1733.
[18]
D C Aron, J B Tyrrell, C B Wilson (1995} Pituitary tumors. Current concepts in diagnosis and management. West J Med.; 162 (4): 340–352.
[19]
K R Ryan, M Hong, P D Arkwright, A R Gennery, C Costigan, M Dominguez, D Denning, V McConnell, A J Cant, M Abinun, G P Spickett, D Lilic (2008) Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED Clin Exp Immunol.; 154 (3): 406–414.
[20]
Omar Bjanid, Piotr Adamczyk, Małgorzata Stojewska, Dagmara Roszkowska-Bjanid, Magdalena Paszyna-Grześkowiak, Agnieszka Jędzura, Joanna Oświęcimska, Katarzyna Ziora, Aurelia Morawiec-Knysak, Maria Szczepańska (2017) Rare case of nephrocalcinosis in a 14-year-old girl: Answers Pediatr Nephrol.; 32 (4): 609–613.
[21]
Preetesh Jain, Luis Baez-Vallecillo, Yang O Huh, Ohad Benjamini, Lynne Abruzzo, Susan O’Brien, Naveen Pemmaraju, Michael Keating, Robert F. Gagel, Zeev Estrov (2014) Atypical chronic lymphocytic leukemia (CLL) with polyglandular autoimmune endocrinopathy (PGA) type II – a complex profile Leuk Lymphoma.; 55 (4): 944–946.
[22]
James W. Verbsky, Talal A. Chatila (2013) Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) and IPEX-Related Disorders: an Evolving Web of Heritable Autoimmune Diseases Curr Opin Pediatr.; 25 (6): 708–714.
[23]
ESP Abstracts 2013 Virchows Arch.; 463 (2): 101–352.
[24]
R Wildin, S Smyk-Pearson, A Filipovich (2002) Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome J Med Genet.; 39 (8): 537–545.
[25]
Omar K. Alkhairy, Nima Rezaei, Robert R. Graham, Hassan Abolhassani, Stephan Borte, Kjell Hultenby, Chenglin Wu, Asghar Aghamohammadi, David A. Williams, Timothy W. Behrens, Lennart Hammarström, Qiang Pan-Hammarström{2015) RAC2 Loss-of-function Mutation in Two Siblings with Characteristics of Common Variable Immunodeficiency J Allergy Clin Immunol.; 135 (5): 1380–1384.e5.
[26]
E. Helen Kemp, Nikos G. Gavalas, Kai J. E. Krohn, Edward M. Brown, Philip F. Watson, Anthony P. Weetman (2009) Activating Autoantibodies against the Calcium-Sensing Receptor Detected in Two Patients with Autoimmune Polyendocrine Syndrome Type 1 J Clin Endocrinol Metab.; 94 (12): 4749–4756.
[27]
Pierre Ronco, Hanna Debiec Pathophysiological lessons from rare associations of immunological disorders Pediatr Nephrol.; 24 (1): 3–8.
[28]
Hans J. J. van der Vliet, Edward E. Nieuwenhuis (2007) IPEX as a Result of Mutations in FOXP3 Clin Dev Immunol.; 2007: 89017.
[29]
G Brancatelli, M Galia, G Sparacia, S Cusma, R Lagalla (2000) Left kidney mass in a 45 year old woman Postgrad Med J.; 76 (901): 722–733.
[30]
F Rorsman, E S Husebye, O Winqvist, E Björk, F A Karlsson, O Kämpe (1995) Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. Proc Natl Acad Sci U S A. 1995; 92 (19): 8626–8629.
[31]
S Singh, A Lone, B Khan, A Khan, M Wani (2000) Shortness of breath and diffuse chest pain Postgrad Med J.; 76 (901): 721–731.
[32]
Alice Poisson, Alain Nicolas, Pierre Cochat, Damien Sanlaville, Caroline Rigard, Hélène de Leersnyder, Patricia Franco, Vincent Des Portes, Patrick Edery, Caroline Demily (2015) Behavioral disturbance and treatment strategies in Smith-Magenis syndrome Orphanet J Rare Dis. 2015; 10: 111.
[33]
The Ulster Medical Journal index: volumes 1-64. (1998) Ulster Med J.; 67 (Suppl 2): 1–60.
[34]
D C Dorman, S L Allen, J Z Byczkowski, L Claudio, J E Fisher, Jr, J W Fisher, G J Harry, A A Li, S L Makris, S Padilla, L G Sultatos, B E Mileson (2001) Methods to identify and characterize developmental neurotoxicity for human health risk assessment. III: pharmacokinetic and pharmacodynamic considerations. Environ Health Perspect.; 109 (Suppl 1): 101–111.
[35]
Abstracts from Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, held in Bonn, Germany, from July 23–27, 2014 Purinergic Signal.; 10 (4): 657–854.
[36]
J. F. Boyd, A. M. MacDonald (1960) Adrenal Cortical Hypoplasia in Siblings Arch Dis Child.; 35 (184): 561–568.
[37]
M J Kupersmith, R M Burde, F A Warren, T G Klingele, L P Frohman, H Mitnick (1988) Autoimmune optic neuropathy: evaluation and treatment. J Neurol Neurosurg Psychiatry.; 51 (11): 1381–1386. J Neurol Neurosurg Psychiatry.; 52 (5): 692.
[38]
N Maskell, R Butland (2003) BTS guidelines for the investigation of a unilateral pleural effusion in adults Thorax.; 58 (Suppl 2): ii8–ii17.
[39]
Carl E. Allen, Stephan Ladisch, Kenneth L. McClain{2015) How I treat Langerhans cell histiocytosis Blood.; 126 (1): 26–35.
[40]
Ilias Attaye, Merel van Andel, Albertus Jozef Kooter (2018) More, less or both? BMJ Case Rep.; 2018: bcr2017222355.
[41]
M. Goust, A. Castaigne, R. Moulias (1974} Delayed hypersensitivity to muscle and thymus in myasthenia gravis and polymyositis Clin Exp Immunol.; 18 (1): 39–47.
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