Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast
Clinical Medicine Research
Volume 9, Issue 1, January 2020, Pages: 11-19
Received: Jan. 14, 2020;
Accepted: Feb. 7, 2020;
Published: Feb. 14, 2020
Views 211 Downloads 53
Tong Shan, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, China; Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
Tsend Ayushi, Mongolian Medical Research Center, International school of Mongolian Traditional Medicine, MNUMS, Ulaanbaatar, Mongolia
Tuul Khalzaibaast, Traditional Medicine Department, Mongolian University Pharmaceutical Sciences, Ulaanbaatar, Mongolia
Lian Bao Chen, Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China
Chao Lu Meng, Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China
Xing An, Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China
Ju Hua Gong, Traditional Chinese Medicine (Mongolian Medicine), Inner Mongolia University for Nationalities, Tongliao, China
Wang Huan, Mongolian Medicine and Pharmaceutical School of Inner Mongolia University for Nationalities, Mongolian Pharmacology Laboratory, Tongliao, China
Follow on us
The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.
Mongolian Medicine Modified Sugmul-7, Hyperplasia of the Breast, Endocrine Function, Proteomics
To cite this article
Lian Bao Chen,
Chao Lu Meng,
Ju Hua Gong,
Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast, Clinical Medicine Research.
Vol. 9, No. 1,
2020, pp. 11-19.
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Z. Ying, H. Wenshan, Wang. Wei, et al. (2009). Screening and epidemiological factors of 75,490 women with breast diseases. Journal of Chinese women's health, 24: 1465-1466.
H. Kefei, G. Qi, P. Xiao Hua et al. (2013). Clinical study on influencing factors of 435 cases of breast hyperplasia. Chinese journal of experimental formulations. 19 (9): 319-322. (in Chinese with English abstract).
Fan F. Ying. (2002). Shallowly talk about the maladjustment and Mammary gland hyperplasia. Journal of Nanjing University of Chinese medicine. 18 (5): 266-267. (in Chinese with English abstract).
Lu Jingbo, Qiu Guifang. (2003) Diagnosis and treatment of 10 cases of Hyperprotinemia. Journal of Medical theory and practice. 16 (1): 56-57.
W. Jieping, Q, Fazu, H. Jiaxiun. Surgery. Beijing: People's medical publishing house, 2002: 829-830. (in Chinese).
Zhao W J, Wang J W, Chang J Z, et al. (2014) Effect of Xianlu Xiaopi capsule on expression of VEGF, bFGF and MVD in breast hyperplasia mice. Shanghai Journal of Traditional Chinese medicine. 48 (3): 74. (in Chinese with English abstract).
Lin Yi, tang hanjun. Modern Chinese medicine on breast disease [M]. Beijing: people's medical publishing house, 2003, 5: 103.
Wang zege. Mongolian medicine and surgery. Hohhot: Inner Mongolia people's publishing house, 1986, 12: 287.
Editorial committee of encyclopedia of Chinese medicine. Encyclopedia of Chinese medicine, Mongolian medicine. Shanghai: Shanghai science and technology press, 1992: 274.
Wang X L, Pharmacology of Mongolian medicine. Hohhot: Inner Mongolia people's publishing house, 2006, 6: 36, 176, 33, 28.
Signaling for contraction and relaxation in smooth muscle of the gut. Annu Rev Physiol 68: 345-74 (2006) DOI: 10.1146/annurev.physiol.68.040504.094707.
Membrane receptor for thyroid hormone: Physiologic and pharmacologic implications. Annu Rev Pharmacol Toxicol 51: 99-115 (2011) DOI: 10.1146/annurev-pharmtox-010510-100512.
Estrogen signaling in the Hypothalamus. Vitam Horm 71: 123-45 (2005) DOI: 10.1016/S0083-6729(05)71005-0.
From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases. Cell Commun Signal 15: 15 (2017) DOI: 10.1186/s12964-017-0171-4.
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch 444: 213-23 (2004) DOI: 10.1007/s00428-003-0947-3.