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Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases
Clinical Medicine Research
Volume 8, Issue 6, November 2019, Pages: 137-143
Received: Oct. 13, 2019; Accepted: Nov. 12, 2019; Published: Dec. 17, 2019
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Carlos Ramirez-Velazquez, Allergy Service of the General Hospital “Fernando Quiroz Gutierrez”, Institute of Security and Social Services of State Workers, Mexico City, Mexico
Juan Carlos Paredes-Palma, Internal Medicine Service of the General Hospital “Fernando Quiroz Gutierrez”, Institute of Security and Social Services of State Workers, Mexico City, Mexico
Sandra Vanesa Patzi-Vargas, Department of Biostatistics and Epidemiology, Center for Research and Continuing Education (CENINVEC), Nezahualcoyotl City, Mexico
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The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.
Natural Killer T Cells, Autoimmune Diseases, Immune System Diseases
To cite this article
Carlos Ramirez-Velazquez, Juan Carlos Paredes-Palma, Sandra Vanesa Patzi-Vargas, Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases, Clinical Medicine Research. Special Issue: Globalization and Advances on Non-Communicable Chronic Diseases. Vol. 8, No. 6, 2019, pp. 137-143. doi: 10.11648/j.cmr.20190806.12
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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