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Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients
Clinical Medicine Research
Volume 7, Issue 1, January 2018, Pages: 1-7
Received: Mar. 10, 2017; Accepted: Apr. 10, 2017; Published: Jan. 26, 2018
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Abidemi Jude Fasae, Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria
Olusegun Adesola Busari, Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria
Rotimi Oluyombo, Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria
Musa Yusuf, Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria
Oladipo George Opadijo, Department of Internal Medicine, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria
Ayodele Babatunde Omotoso, Department of Internal Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria
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The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p<0.0001). There was an association between Hyperuricemia and left ventricular hypertrophy (x2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.
Hyperuricemia, Target Organ Damage, Electrocardiographic Changes, Hypertensive Nigerians
To cite this article
Abidemi Jude Fasae, Olusegun Adesola Busari, Rotimi Oluyombo, Musa Yusuf, Oladipo George Opadijo, Ayodele Babatunde Omotoso, Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients, Clinical Medicine Research. Vol. 7, No. 1, 2018, pp. 1-7. doi: 10.11648/j.cmr.20180701.11
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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