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Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report
Clinical Medicine Research
Volume 6, Issue 4, July 2017, Pages: 127-130
Received: Feb. 13, 2017; Accepted: Apr. 24, 2017; Published: Jun. 14, 2017
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Molina-Arrebola María-Angustias, Department of Biotechnology, Haematology and Haemotherapy Unit, Poniente Hospital, Almería, Spain
Fernández-Caballero Mariana, Department of Biotechnology, Haematology and Haemotherapy Unit, Poniente Hospital, Almería, Spain
Avivar-Oyonarte Cristóbal, Department of Biotechnology, Poniente Hospital, Almería, Spain
Jiménez-Cortés María-Carmen, Department of Biotechnology, Pathology Unit, Poniente Hospital, Almería, Spain
Hidalgo-Rico María-Angeles, Department of Internal Medicine, Pulmonology Unit, Poniente Hospital, Almería, Spain
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Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.
Bone Marrow, Metastases, Solid Tumour, Immunohistochemistry
To cite this article
Molina-Arrebola María-Angustias, Fernández-Caballero Mariana, Avivar-Oyonarte Cristóbal, Jiménez-Cortés María-Carmen, Hidalgo-Rico María-Angeles, Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report, Clinical Medicine Research. Vol. 6, No. 4, 2017, pp. 127-130. doi: 10.11648/j.cmr.20170604.12
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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