Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism
Clinical Medicine Research
Volume 6, Issue 3, May 2017, Pages: 106-110
Received: May 4, 2017; Published: May 4, 2017
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Authors
Hou Zhenjiang, Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Mu Zhaoxin, Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Zhang Jingyu, Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Fan Hong, Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Hou Jianzhang, Department of Surgery, Cangzhou People's Hospital, Cangzhou Medical College, Cangzhou, China
Wang Hongsheng, Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
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Abstract
To investigate the correlation between hypothyroidism and subclinical hypothyroidism in serum thyroid hormones, blood lipid profile, blood lipid ratio and homocysteine, the authors calculated the ratio of blood lipid and carried on statistical analysis through measuring the level of serum thyroid hormones, blood lipid, homocysteine among 60 patients with hypothyroidism, 140 patients with subclinical hypothyroidism and 60 controls. As a result, firstly, the levels of serum TSH in hypothyroidism group and subclinical hypothyroidism group were significantly higher than those in the control group (P <0.001).The difference between the subclinical hypothyroidism group and the control group had statistical significance (P <0.05).What’s more, the patients, who were hypothyroidism, were significantly lower than those in the control group in the levels of serum FT3 and FT4. Moreover, compared with the hypothyroidism and subclinical hypothyroidism, on the one hand, the levels of serum FT3 and FT4 obviously decreased, on the other hand, the levels of serum TSH and Hcy were significantly increased (P <0.01). As to the correlation of thyroid hormones with blood lipid ratio and non-HDL-C, TC showed the highest correlation and the sequences were non-HDL-C, LDL-C and LCI. In the end, the authors came to the conclusion that the detection of serum TSH, blood lipid ratio and Hcy were of great value in the transformation from subclinical hypothyroidism to hypothyroidism and the prediction of hypothyroidism and the cause of cardiovascular diseases.
Keywords
Hypothyroidism, Subclinical Hypothyroidism, Thyroid Hormone, Blood Lipid Ratio, Homocysteine
To cite this article
Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang, Wang Hongsheng, Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism, Clinical Medicine Research. Vol. 6, No. 3, 2017, pp. 106-110. doi: 10.11648/j.cmr.20170603.18
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