Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia
Clinical Medicine Research
Volume 6, Issue 3, May 2017, Pages: 80-85
Received: Feb. 21, 2017; Accepted: Mar. 21, 2017; Published: Apr. 10, 2017
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Weiting Wang, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Chunhua Hao, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Rui Zhang, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Yinzhong Ma, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Shuangyong Sun, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Zhuanyou Zhao, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Lida Tang, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
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Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.
Experimental Methodology, Anesthetics, Myocardial Ischemia-Reperfusion, Inflammatory Factor
To cite this article
Weiting Wang, Chunhua Hao, Rui Zhang, Yinzhong Ma, Shuangyong Sun, Zhuanyou Zhao, Lida Tang, Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia, Clinical Medicine Research. Vol. 6, No. 3, 2017, pp. 80-85. doi: 10.11648/j.cmr.20170603.14
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sheu JJ, Chang LT, Chiang CH, Youssef AA, Wu CJ, Lee FY, Yip HK. Prognostic value of activated toll-like receptor-4 in monocytes following acute myocardial infarction. Int Heart J. 2008; 49(1): 1–11.
Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res. 2002; 53(1): 31–47.
Lambert JM, Lopez EF, Lindsey ML. Macrophage roles following myocardial infarction. Int J Cardiol. 2008; 130(2): 147–158.
Frangogiannis NG. The immune system and cardiac repair. Pharmacol Res. 2008; 58(2): 88–111.
Sheu JJ, Chua S, Sun CK, Chang LT, Yen CH, Wu CJ, Fu M, Yip HK. Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction. Int J Cardiol. 2011; 147(1): 79–87.
Chua S, Leu S, Sheu JJ, Lin YC, Chang LT, Kao YH, Yen CH, Tsai TH, Chen YL, Chang HW. et al. Intra-coronary administration of tacrolimus markedly attenuates infarct size and preserves heart function in porcine myocardial infarction. J Inflamm (Lond). 2012; 9(1): 21.
Yang CH, Sheu JJ, Tsai TH, Chua S, Chang LT, Chang HW, Lee FY, Chen YL, Chung SY, Sun CK. et al. Effect of tacrolimus on myocardial infarction is associated with inflammation, ROS, MAP kinase and Akt pathways in mini-pigs. J Atheroscler Thromb. 2013; 20(1): 9–22.
Jiunn-Jye Sheu, Pei-Hsun Sung, Steve Leu, Han-Tan Chai, Yen-Yi Zhen, Yi-Ching Chen, Sarah Chua, Yung-Lung Chen, Tzu-Hsien Tsai, Fan-Yen Lee, Hsueh-Wen Chang, Sheung-Fat Ko, and Hon-Kan Yip. Innate immune response after acute myocardial infarction and pharmacomodulatory action of tacrolimus in reducing infarct size and preserving myocardial integrity. J Biomed Sci. 2013; 20 (1): 82.
Saxena A, Russo I, Frangogiannis NG. Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges. Transl Res. 2015; 167(1): 152–166.
Timmers L, Pasterkamp G, de Hoog VC, Arslan F, Appelman Y, de Kleijn DP. The innate immune response in reperfused myocardium. Cardiovasc Res. 2012; 94(2): 276–283.
Zarrouk-Mahjoub S, Zaghdoudi M, Amira Z, Chebi H, Khabouchi N, Finsterer J, Mechmeche R, Ghazouani E. Pro- and anti-inflammatory cytokines in post-infarction left ventricular remodeling. Int J Cardiol. 2016; 221: 632-6.
Landoni G, Fochi O, Tritapepe L, Guarracino F, Belloni I, Bignami E, Zangrillo A. Cardiac protection by volatile anesthetics. Minerva Anestesiol. 2009; 75 (5): 269-73.
Stadnicka A, Marinovic J, Ljubkovic M, Bienengraeber MW, Bosnjak ZJ. Volatile anesthetic-induced cardiac preconditioning. J Anesth. 2007; 21 (2): 212-9.
Anesthetic cardioprotection: the role of adenosine. Bonney S, Hughes K, Eckle T. Curr Pharm Des. 2014; 20 (36): 5690-5.
Lang XE1, Wang X, Zhang KR, Lv JY, Jin JH, Li QS. Isoflurane preconditioning confers cardioprotection by activation of ALDH2. PLoS One. 2013; 8 (2): e52469.
Qiao S, Xie H, Wang C, Wu X, Liu H, Liu C. Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy. J Anesth. 2013; 27 (2):251-60.
Annecke T1, Chappell D, Chen C, Jacob M, Welsch U, Sommerhoff CP, Rehm M, Conzen PF, Becker BF. Sevoflurane preserves the endothelial glycocalyx against ischaemia-reperfusion injury. Br J Anaesth. 2010; 104 (4):414-21.
Hieber S1, Huhn R, Hollmann MW, Weber NC, Preckel B. Hypoxia-inducible factor 1 and related gene products in anaesthetic-induced preconditioning. Eur J Anaesthesiol. 2009; 26 (3): 201-6.
Pratt PF Jr, Wang C, Weihrauch D, Bienengraeber MW, Kersten JR, Pagel PS, Warltier DC. Cardioprotection by volatile anesthetics: new applications for old drugs? Curr Opin Anaesthesiol. 2006; 19 (4): 397-403.
Hara T. Cardioprotection by anesthetics]. [Article in Japanese]. Masui. 2006; 55 (5): 552-9.
Galley HF, Dubbels AM, Webster NR. The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes. Anesth Analg. 1998; 86 (6): 1289-93.
Ren Jianjun, Dong Zhenm ing, Zhao Yuyi. The effects of p ropofol on th e expression of nu clear factor-kappa B and cell apoptosis of ischemia reperfusion myocardium in rabbits. Hebei Medical Journa l. 2009; 31 (19): 2541-2543.
Wu Y, Wan J, Zhen WZ, Chen LF, Zhan J, Ke JJ, Zhang ZZ, Wang YL. The effect of butorphanol postconditioning on myocardial ischaemia reperfusion injury in rats. Interact Cardiovasc Thorac Surg. 2014; 18 (3): 308-12.
Kong XY, Hu CY, Liu J, Luo Cz. Cardioprotective Effects of Emulsified Isoflurane Postconditioning against Ischemia Reperfusion Injury in Rat Heart and Its Mechanisms. West China Medical Journal. 2015; 30(8): 1461-1464.
Wang C, Neff DA, Krolikowski JG, Weihrauch D, Bienengraeber M, Warltier DC, Kersten JR, Pagel PS. The Influence of B-Cell Lymphoma 2 Protein, an Antiapoptotic Regulator of Mitochondrial Permeability Transition, on Isoflurane-Induced and Ischemic Postconditioning in Rabbits. Anesth Analg. 2006; 102 (5): 1355-60.
Ran Ke, Duan Kaiming, Zou Dingquan, Li Zhijian, Jin Liyan, Chang Yetian. Effect of isoflurane delayed preconditioning om myocardial ischemia reperfusion injury in rabbits. J Cent South Univ (Med Sci), 2008; 33 (2): 146-150.
Kinoshita M, Tsutsumi YM, Fukuta K, Kasai A, Tanaka K. Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels. J Med Invest. 2016; 63 (1-2): 80-4.
Li Yong, Ge Yali, Yang Liuqing, Yu Dapeng, Gao Ju, Fu Peng. Effect of Sevoflurane Postconditioning on the Levels of IL-8 and IL-10 and on the Ultramicrostructure of Myocardial Tissue after Myocardial Ischemia Reperfusion in Mature Rabbits. Journal of Military Surgeonin Southwest China, 2015; 17 (06): 618-621.
Liu Jinyuan, Si Linjie. Protective preconditioning effect and mechanism of tartaric acid Bhutto on myocardial ischemia reperfusion injury in mice. Journal of Southeast University (Medical Science), 2017; 36(1): 74-77.
Qin Wenyan, Liu Baojiang, Tian Shouyuan. The effects of Isoflurane on acute myocardial infarction in rat. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease. 2008; 6 (6): 667-669.
Chen Quan, Liu Guoli, Li Ping, Zhang Jinying. Effects of isoflurane preconditioning on myocardial cells and the expression of ICAM-1 and NF-κ B after ischemia reperfusion in immature rabbits. Shaanxi Medical Journal. 2011; 40 (1): 7-10.
Zhong C, Zhou Y, Liu H. Nuclear factor kappaB and anesthetic preconditioning during myocardial ischemia-reperfusion. Anesthesiology. 2004; 100 (3): 540-6.
Lutz M, Liu H. Inhaled sevoflurane produces better delayed myocardial protection at 48 versus 24 hours after exposure. Anesth Analg. 2006; 102 (4): 984-90.
Xie Lijun, Zhang Jianxin, Li Lanfang, Zhang Lezeng, Hao Na, Li Liping, Li Guofeng. Protective effect of propofol on myocardium ischemia/reperfusion injury in rat. Chinese Journal of Pharmacology and Toxicology. 2011; 25 (1): 7-12.
Wang Hongjie, Su Hong, Zhang Jianxin, Xie Lijun, Liu Fang, Su Xiaohua. Effects of propofol on inflammatory response induced by myocardium ischemia/reperfusion in diabetic rats. Hebei Medical Journal. 2013; 35 (24): 3685-3688.
Zhao Wenhui, Chen Jun, Jing Guixia, Liu Jian, Dang Xiaodong. Effects of propofol on the changes in myocardial Toll-like receptor 4 and TNF–alpha and NF –kb protein expressions and ultrastructure in ischemia-reperfusion inhury in rat. Journal of Xi’an Jiaotong University (Medical Sciences), 2014; 35 (3): 357-360.
Yan Xuetao, Wu Yun, Zheng Wenzhong, et al. The Effects of Butorphanol Postconditioning on Myocardial Factor of Rats with Ischemical Reperfusion Injury. Journal of Hubei University for Nationalities Medical Edition, 2001; 28 (2): 1-3.
Liu Xun-qin, Gu Er-wei, Zhang Lei, et al. Effect of emulsified isoflurane preconditioning on myocardial ischemia-reperfusion injury in rabbits. Chinese Journal of Anesthesilolgy, 2010; 30 (4): 480-483.
Kong Xiang-yun, Hu Zhao-yang, Liu Jin, Luo Chao-zhi. Emulsified Isoflurane Induces Postconditioning against Myocardial Ischemia and Reperfusion Injury in Rats. West China Medical Journal. 2015; 30 (8): 1461-1464.
Wu Zhilin, Chu Shuj uan, Yao Shanglong et al. Effects of Different Dosages of Dexmeditomidine Pretreatment on Myocardial Ischemia Reperfusion Injury and Inflammation in Rats. Journal of Huazhong University of Science and Technology(Health Sciences). 2015; 44 (4): 445-447.
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