Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis
Clinical Medicine Research
Volume 5, Issue 4, July 2016, Pages: 77-81
Received: Jun. 14, 2016; Published: Jun. 15, 2016
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Authors
Rigen Wu, Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
Zhiqiang Kang, Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
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Abstract
In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.
Keywords
Brain Retractor, Brain Retraction, Lactic Acid, Glycerol, Biochemical Metabolism, Microdialysis
To cite this article
Rigen Wu, Zhiqiang Kang, Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis, Clinical Medicine Research. Vol. 5, No. 4, 2016, pp. 77-81. doi: 10.11648/j.cmr.20160504.13
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