Pressure lowering effect of fixed combination and unfixed- combination of latanoprost and timolol in Asian population
Clinical Medicine Research
Volume 1, Issue 1, December 2012, Pages: 7-12
Received: Dec. 15, 2012; Published: Dec. 30, 2012
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Seyed Ali Asghar Mosavi, Dept. Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Malaysia
Ch’ng Tun Wang, Dept. Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Malaysia
Azhany Yaakub, Dept. Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Malaysia
Nik Azlan Zaid, Dept. Ophthalmology, Hospital Raja Perempuan Zainab II, Jalan Hospital, Kelantan, Malaysia
Liza-Sharmini Ahmad Tajudin, Dept. Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Malaysia
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Introduction: Fixed combination of topical pressure lowering drugs such as latanoprost and timolol (FCLT) has been reported to improve adherence and persistence to medication for chronic disease such as glaucoma. However, its effectiveness has been reported to be less compared to unfixed combination of latanoprost and timolol (UFCLT). Objective: To compare the efficacy of FCLT and UFCLT in Malaysian population. Methods: A non randomized prospective cohort study was conducted from January 2006 to December 2010 involving primary open-angle glaucoma (POAG), ocular hypertension (OHT) and normal-tension glaucoma (NTG) patients who failed to achieve target pressure or demonstrated progression of the disease while on monotherapy treatment with topical timolol XE 0.5% in eye clinic of Hospital Universiti Sains Malaysia and Hospital Raja Perempuan Zainab II, Kelantan, Malaysia. A total of 120 glaucoma patients were recruited with 58 were prescribed FCLT and 62 were treated with UFCLT. UFCLT is combination of topical timolol XE 0.5% and latanoprost 0.005%. Intraocular pressure (IOP) was taken at baseline and 3, 6, 9, 12 months post treatment. Results: A total of 95 patients completed the 12 months follow up (47 in FCLT group and 48 in UFCLT). Mean age was 61.0 SD 14.5 years old. Majority of cases were POAG (79%), followed by NTG (12%) and OHT (9%). Mean baseline IOP was 23.9 SD 5.9 mmHg and 19.9 SD 5.6 mmHg in UFCLT and FCLT groups respectively. Mean IOP reduction between baseline and final measurement in UFCLT and FCLT groups were -8.1 mmHg vs.-3.6 mmHg respectively (p<0.001). Based on repeated measures analysis of variance (RM ANOVA) and repeated measures analysis of covariance (RM ANCOVA) model, there was significant difference between UFCLT and FCLT (p =0.002). Conclusions: Both UFCLT and FCLT provide pressure lowering effect in Malaysian population. UFCLT provides significant better pressure lowering effect than FCLT. FCLT provides less inter-visit pressure fluctuation.
Combination Therapy, Latanoprost, Timolol, Ocular Hypertension, Open-Angle Glaucoma, Normal-Tension Glaucoma
To cite this article
Seyed Ali Asghar Mosavi, Ch’ng Tun Wang, Azhany Yaakub, Nik Azlan Zaid, Liza-Sharmini Ahmad Tajudin, Pressure lowering effect of fixed combination and unfixed- combination of latanoprost and timolol in Asian population, Clinical Medicine Research. Vol. 1, No. 1, 2012, pp. 7-12. doi: 10.11648/j.cmr.20120101.12
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