Isoniazid Containing Metal Based Drugs as Potential Antimicrobial Agent: A Short Review
Science Journal of Chemistry
Volume 5, Issue 5, October 2017, Pages: 62-70
Received: Jul. 17, 2017; Accepted: Jul. 31, 2017; Published: Sep. 18, 2017
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Md. Saddam Hossain, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Md. Abdul Mannan, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
F. K. Camellia, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
A. K. B. Zaman, Department of Dermatology, Barind Medical College and Hospital, Rajshahi, Bangladesh
C. M. Zakaria, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Md. Kudrat-E-Zahan, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
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Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review we have focused on research undertaken over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-tuberculosis, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of isoniazid containing synthetic metal complexes.
Metal Based Drugs, Antibacterial, Antifungal, Anti-Tuberculosis, Anti-Cancer, DNA-Interaction and Anti-Tumor Activity
To cite this article
Md. Saddam Hossain, Md. Abdul Mannan, F. K. Camellia, A. K. B. Zaman, C. M. Zakaria, Md. Kudrat-E-Zahan, Isoniazid Containing Metal Based Drugs as Potential Antimicrobial Agent: A Short Review, Science Journal of Chemistry. Vol. 5, No. 5, 2017, pp. 62-70. doi: 10.11648/j.sjc.20170505.11
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Zhang, Y.; Young, D. B. (1993) Molecular mechanisms of isoniazid: A drug at the front line of tuberculosis control. Trends Microbial., 1, 109–113.
Vikramjeet, J.; Balasubramanian, N.; Munish, A. (2012) Isoniazid: The magic molecule. Med. Chem. Res., 21, 3940–3957.
WHO, 2009, Treatment of tuberculosis: guidelines. WHO, 2012, Global Tuberculosis Control: WHO report 2011.
M. C. D. S. Lourenco, M. D. L. Ferreira, M. V. N. De Souza, M. A. Peralta, T. R. A. Vasconcelos, M. D. O. Henriques, Eur. J. Med. Chem. 43, 1344 (2008).
T. Aboul-Fadl, F. A. S. Bin-Jubair, O. Aboul-Wafa, (2010)Eur. J. of Med. Chem. 45, 4578.
M. Shahar Yar, M. A. Ali, M. M. Abdullah, (2007) Med. Chem. Res., 16, 292.
M. V. N. De Souza, Drug Discovery 1, 33 (2006).
T. Aboul-Fadl, H. A. Abdel-Aziz, M. K. Abdel-Hamid, T. Elsaman, J. Thanassi, M. J. Pucci, Molecules 16, 7864 (2011).
Bamigboye M. O, Obaleye J. A Lawal M. and Aluko O. M, (2012) Synthesis, Characterization and Antimicrobial Study Of Mixed Isoniazid-Trimethoprim Metal Drug Complexes. Chemistry and Materials Research. 2(3): 1-8.
Ogunniran Kehinde, Adekoya Joseph, Ehi-Eromosele Cyrila, Siyanbola Tolutope, Aladesuyi Olanrewaju, Ajanaku Christiana, Akinlolu Kayode, Mehdi Shihab Salih and Narender vTadigoppula. (2016) Synthesis, Characterization, Theoretical Treatment and Antitubercular activity Evaluation of (E)-N’-(2,5-dimethoxylbenzylidene)nicotinohydrazide and some of its Transition Metal Complexes against Mycobacterium tuberculosis, H37Rv. Orient. J. Chem., Vol. 32(1): 413-427.
Angila kriza, Lucica Viorica Ababe, Nicoleta Ciotera, Ileana Rau and Nicole Stanica. (2010) Synthesis and structural studies of complexes of Cu, Co, Ni and Zn with isonicotinic acid hydrazide and isonicotinic acid (1-naphthylmethylene) hydrazide. J. Serb. Chem. Soc. 75 (2): 229–242.
Evans N. Mainsah, Sally-Judith E. Ntum, Moses Samje, Fidelis Cho-Ngwa, Peter T. Ndifonand Joseph N. Yong. (2016) Synthesis and Anti-onchocercal Activity of Isonicotinoylhydrazones and their Copper(II) and Zinc(II) Complexes. Anti-Infective Agents, 14(1): 47-52.
Kehinde Olurotimi Ogunnirana, Joseph Adeyemi Adekoyaa, Cyril Ehi-Eromoselea, Olayinka Oyewale Ajania, Akinlolu Kayodea and Tadigoppula Narender. (2016) (E)-N'-(2, 4 dihydroxybenzylidene) nicotinohydrazide and its Metal Complexes: Synthesis, Characterisation and Antitubercular Activity. Pak. j. sci. ind. res. Ser. A: phys. sci. 59(2): 63-75.
Kehinde O. Ogunniran, Joseph A. Adekoya, Cyril O. Ehi-Eromosele, Tolutope O. Siyanbda, Akinlolu Kayode, Micheal A. Mesubi and Tadigoppula Narender. (2015) Transition Metal Complexes of (E)-N’-(4-cyanobenzylidene) nicotinohydrazide): Synthesis, Structural and Anti-Mycobacterial Activity Study. Journal of Applied Sciences, 15 (10): 1210-1222.
Elena Pahont, Diana-Carolina Ilies, Sergiu Shova, Camelia Oprean, Virgil Paunescu, Octavian Tudorel Olaru, (2017) Synthesis, Characterization, Antimicrobial and Antiproliferative Activity Evaluation of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) Complexes with Isoniazid-Derived Compound. Molecules, 22: 650.
Eduardo Henrique Silva Sousa, Luiz Augusto Basso, Dio´genes S. Santos, Izaura Cirino Nogueira Dio´genes. (2012) Elisane Longhinotti, Luiz Gonzaga de Franc¸a Lopes, I´caro de Sousa Moreira. Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design. J Biol Inorg Chem 17: 275–283.
D lesudurai & S Vancheesan, (2003) Coordination of isoniazid, an anti-tuberculosis (TB) drug with chromium, molybdenum, and tungsten metal carbonyls. Indian Journal of Chemistry, 42(A): 1609-1616.
Inara de Aguiar, Aline Tavares, Antonio. Roveda Jr. Augusto C. H. da Silva, Leonardo B. Marino, Érica O. Lopes, Fernando R. Pavan, Luiz G. F. Lopes. (2015) Antitubercular activity of Ru (II) isoniazid complexes. European Journal of Pharmaceutical Sciences 70: 45–54.
N. Panda, S. K. Tripathy, N. K. Behera, A. K. Panda1, P. K. Das, (2015) Synthesis, Spectroscopic and Anti-microbial studies of Binuclear Schiff Base Complexes derived from the Ligand prepared from Isoniazid and Benzilmonohydrazone. International Journal of Innovative Science, Engineering & Technology, 2(4): 783-795.
A Bekierkunst, (1966) Nicotinamide-Adenine Dinucleotide in Tubercle Bacilli Exposed to Isoniazid, Science, 152(3721): 525.
Ladislav Habala, Samuel Varényi, Andrea Bilkova, (2016) Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes, Molecules, 21(12): 1742.
Gisele S. S. Firmino, Marcus Vinicius Nora de Souza, Claudia Pessoa, Josane A. Lessa, (2016) Synthesis and evaluation of copper(II) complexes with isoniazid-derived hydrazones as anticancer and antitubercular agents. Bio Metals 29(6): 47-51.
M. K. Prasanna, K. K. Pradeep, (2013) Synthesis, characterisation and antimicrobial studies of transition metal complexes of 2-hydroxy-5-methoxybenzaldehydeisonicotinoylhydrazone. Research Journal of Chemistry and Environment, 17(6): 61-67.
Krishna K. Sharma, Ritu Singh, Nighat Fahmi, R V Singh. (2010) Synthesis, coordination behavior, and investigations of pharmacological effects of some transition metal complexes with isoniazid Schiff bases. Journal of Coordination Chemistry 63(17): 3071-3082.
N. V. Loginova, T. V. Koval'chuk, V. M. Shkumatov, (2014) Redox-Active Silver(I) Complexes with Sterically Hindered 1,2-Dihydroxybenzene Derivatives: Reduction of Cytochrome c and Antimicrobial Activity. Cytochromes b and c: Biochemical Properties, Biological Functions, and Electrochemical Analysis, Chapter: 5, Publisher: Nova Science Publishers, Inc., Editors: Rurik Thom, 121-171.
S. B. Kalia, Kamakshi Lumba, P. Sankhyan, (2011) Magnetic and spectral studies on nickel(II) and copper(II) dithiocarbazates derived from isoniazid. Journal of Coordination Chemistry, 64(7): 1216-1228.
Ding-Wa Zhang, Zheng-Yin Yang, Ru-Dong Yang, (2006) Synthesis, Characterization and Relaxation Properties of Four Non-ion Transition Metal Manganese(II), Cobalt(II), Nickel(II) and Copper (II) Complexes with Derivatives from Diethylene Triamine Pentaacetic Acid and Isoniazid. Transition Metal Chemistry, 31(3): 333-336.
Zheng-Yin Yang, Ru-Dong Yang, Kai-Bei Yu, (2000) Crystal structure and antitumor activity of some rare earth metal complexes with Schiff base. Polyhedron, 19(26-27): 2599-2604.
Zahid H Chohan, M. Arif, Zahid Shafiq, Muhammad Yaqub, (2006) In vitro antibacterial, antifungal & cytotoxic activity of some isonicotinoylhydrazide Schiff’s bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes, Journal of Enzyme Inhibition and Medicinal Chemistry, February; 21(1): 95–103.
Arun Srivastava, (2014) Antiviral Activity of Copper Complexes of Isoniazid against RNA Tumor Viruses, Resonance, 754-760.
Zheng-Yin Yang, (2000) Synthesis, Characterization and Scavenger Effects on O2− of 3d Transition Metal Complexes of Isonicotinoyl Hydrazone Derived from Isoniazid with PMBP, Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 30(7): 1265-1271.
K P Deepa, K. K. Aravindakshan, (2004) Synthesis, Characterization, and Antifungal Studies of Transition Metal Complexes of ω-Bromoacetoacetanilide Isonicotinylhydrazone, Applied Biochemistry and Biotechnology 118(1-3): 283-92.
Jesudural D, S. Vancheesan, (2003) Coordination of isoniazid, an anti- tuberculosis (TB) drug with chromium, molybdenum, and tungsten metal carbonyls, Indian Journal of Chemistry Section a 42A(7): 1 609-1616.
Shamsher Singh Kanwar, Kamakshi Lumba, S. B. Kalia, (2008) Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldi thiocarbazic acid. Biotechnology Letters 30(4): 677-80.
A Cole, P M May, D R Williams, (1983) Metal binding by pharmaceuticals. Part 3. Copper (II) and zinc (II) interactions with isoniazid, Agents and Actions 13(1): 91-97.
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