Analgesic Properties of Euphorbia prostrate Crude Extracts
Science Journal of Chemistry
Volume 3, Issue 6, December 2015, Pages: 100-105
Received: Oct. 20, 2015; Accepted: Nov. 2, 2015; Published: Dec. 8, 2015
Views 3336      Downloads 73
Authors
Biwott T., Department of Chemistry, Moi University, Kenya, Eldoret
Kiprop A., Department of Chemistry, Moi University, Kenya, Eldoret
Cherutoi J., Department of Chemistry, Moi University, Kenya, Eldoret
Munyendo W., Department of Chemistry, Moi University, Kenya, Eldoret
Biwott G., Department of Biological Sciences, University of Eldoret, Kenya, Eldoret
Article Tools
Follow on us
Abstract
Pain is a symptom that results from particular physiological processes as injurious stimuli characteristic of cell injury or disease. The use of plants as medicine for relieving pain has been reported in several studies where extracts have shown significant analgesic activity. This study was conducted to determine the analgesic efficacy of ethyl acetate and hexane crude extract from Euphorbia prostrate. The phytochemical screening of hexane and ethyl acetate was done. The study also evaluated the analgesic properties of hexane and ethyl acetate crude extracts from E. prostrate. Tail Immersion Model with albino rats was adopted for the investigation. Crude extracts at doses of 250, 500 and 1000mg/kg body weight were administered orally and their activity compared with diclofenac (positive control) and tween solution (negative control). Phytochemical screening showed that major phytochemical in E. prostrate plant had mid polar properties. Results for both the hexane and ethyl acetate crude extracts showed a significant increase in Pain Reaction Time (PRT) at the dose level of 1000 mg/kg. These results were statistically authentic as realized from minimal standard deviation of 0.158 and 0.058 for diclofenac and ethyl acetate extract respectively with a t-test value of 24.99at α = 0.005 level of significance. This confirmed the efficacy of both hexane and ethyl acetate extracts therefore inference that E. prostrate exhibits analgesic activity and is a potential lead candidate for drug discovery.
Keywords
Analgesic, Diclofenac, Tail Immersion, Euphorbia prostrate
To cite this article
Biwott T., Kiprop A., Cherutoi J., Munyendo W., Biwott G., Analgesic Properties of Euphorbia prostrate Crude Extracts, Science Journal of Chemistry. Vol. 3, No. 6, 2015, pp. 100-105. doi: 10.11648/j.sjc.20150306.14
Copyright
Copyright © 2015 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
A. Gilanand A. Rahman (2005). Trends in Ethno pharmacology. Journal of Ethnopharmacology. 100: 43-49.
[2]
A. Gilani, and A. Rahman, (2005). Trends in ethno pharmacology. Journalof Ethnopharmacology. 100: 43-49.
[3]
W. Abdul, G. Mahreen, B., Syed, N. Muhammad, K. Ajmal, G. Ruksana, (2013). Phytochemical and analysis of medicinal plants occurring in local Area of Mardan. Biochemistry and analytical chemistry. 2: 4.
[4]
B. Ali, G. Blunden, M. Tanira, A. Nemmar (2008). Somephytochemical, Pharmacological and toxicological Properties of ginger (Zingiberofficinale Roscoe): a review of recent research. Food and chemical Toxicology, 46(2), 409-420.
[5]
B. Panda, K. Gaur, M. Kori, L. Tyagi, R. Nema, C. Sharma, &A. Jain, (2009). Anti-inflamatory and Analgesic Activity of Jatropha Gossypifolia in Experimental Animal models. Global Journal of Pharmacology, 3: 1-5.
[6]
C. Evangeline, P. Jusal, G. Quanico, G. Perez (2009). Analgesic activity of extracts of Kilingamonocephala. Pharmaceutical biology. 47: 624-627.
[7]
C. Khare (2007). Indian medicinal Plants: an illustrated dictionary. Springe Science & Business Media.
[8]
C. Wiart, (2007). Ethnophamarcology of medicinal plants. Human press incorporated.
[9]
D. Parmar, & S. Jadav, (2008). An Overview of the articles published in the Indian Journal of Pharmacology during the year 2007. Indian journal of pharmacology, 40(6), 283-284.
[10]
H. Edeoga, D. Okwo, B. Mbaebie (2005). Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology. 4: 685-688.
[11]
J. Soberon M. Sgariglia, C. Jimenez, M. Andian, F. Aguilsar, A. Pastoriza, F Villafane, D. Sampietro and Vattuone, M. (2013). Antifungal activity of Euphorbia prostrata (Aiton) ethanol/aqueous extract against Candida albicans strains. Traditional medicine.
[12]
K. Gunjan, M. Jalaluddin, M. Rajat, & C. Dileep (2013). Emerging trends of herbal care in dentisttry. Journal of clinical and Diagnostic Research 2 28: 1827-1829.
[13]
K. Anil, G. Kayita, D. Jyotsana and S. Pankaj (2011). Analgesic activity of methanolicextract of Flemingiastrobilifera (R. Br). International Journal of Research in Pharmacy and Chemistry. 1: 2231-2781.
[14]
K. Christopher, T. Dennis & D. Jeffrey, (2014). Anti- diabetic and hypolipidaemic effect of botanicals: a review of medicinal weeds on KNUST campus, Kumasi. Journal of applied Pharmaceuticals Science. 4: 097-104.
[15]
M. Blumenthal, A. Goldberg, & J. Brinckmann (2000). Herbal Medicine. Expanded Commission E. monographs. Integrative Medicine Communications.
[16]
M. Chelaiah & A. Muniappan (2006). Medicinnal plants used by traditional healers in Kancheepuran District of Tamil Nadu, India. Journal of ethnobiology and Ethno medicine, 10: 1746-4269.
[17]
M. Ezeja, Y. Omeh, I. Ezeigbo & A. Ekechukwu (2011). Evaluation of the Analgesic Activityof the ethanolic Stem Bark Etraction of Dialium Guineense (wild). Annals of Medica and Health Sciences Research, 1: 1-55.
[18]
M. Shashank, K. Ajay, J. Manoj, & M Cathrin (2013). Analgesic and anti-inflamatory Activity of Kalanchoe Pinnata (Lam). Journal of Medicinal Plants studies1: 24-28.
[19]
M. Kennedy, (2004). A Brief History of Disease, Science, and Medicine: From the Ice Age to the Genome Project.
[20]
N. Savithramma, M. Linga and D. Suhrulatha (2011). Screening of Medicinal plants for secondary metabolites. Middle – East Journal of scientific Research8: 579 – 584.
[21]
O. Kharissova, H. Dias, B. Kharisov, B. Pérez, & V. Pérez (2013). The Greener synthesis of nanoparticles. Trends in biotechnology, 31(4), 240-248.
[22]
P. Ljubuncic, Azaizen, H., Portanaya, I., Cogan, U., Said, O., Saleh, K., Bomzon, A. Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel. Journal of Ethnopharmacology. 99: 43-47
[23]
P. Gupta (2011). Efficacy of Euphorbia prostrata in early grades of symptomatic hemorroids- a pilot study. European review for medical and pharmacological sciences, 15: 199-203.
[24]
P. Uma- Devi, I Ganasounder, S. Rao and K. Srivasan (1999). Invitro Radioprotection by Ocimumflavanoids. Survival of Rats.
[25]
P. Singla and K. Pathak, (1990). Topical anti-inflammatory of Euphorbiaprostrata on Carrageena –induced footpad oedema in mice. Journal of ethno pharmacological. 29: 291-294.
[26]
R. Kamang, K.Gonsu, P.Wafo, J Mbungni, E. Pukam, T. Fokam, M. Fonkoua (2007). Activity of aqueous ethanol extract of Euphorbia prostrataait on Shigelladystentriae type 1 – induced diarrhea in rats. Indian Journal of pharmacology. 5: 240-244.
[27]
S. Prusti, Mishra, M. Sahoo, S. Mishra, (2008). Ethnobotanical leaflets. 12: 227-230.
[28]
S. Rui-Qinq, T. Yi-Jun, B. Nada, Y. Jing-Yin, L. Qing and D. William (2004). Journal of neurophysiology. 92: 2859-2004.
[29]
S. Ozbilgin, & G. Saltan, (2012). Uses of some Euphorbia species in traditional medicines in Turkey and their Biological activities. Turkey Journal of Pharmacological science, 9: 241-256.
[30]
S. Fabricant & N. Farnsworth (2001). The value of plants used in traditional Medicine for drug discovery. Environmental Health perspectives, 109: 69.
[31]
S. Saeed -Ul –Hassan, U. Bhatti, M. Khali –Ur-Rehman, U. Naiz, I. Waheed, S. Rasool & I.Tariq (2013). Irritants effects of euphorbia prostrata. African Journal of Pharmacy and pharmacology, 7: 2321-2332.
[32]
S. Sasidharan, Y. Chen, D. Saravanan, K. Sundram & L. Latha (2011). Extraction, Isolation and characterization of bioactive Compounds from plants’ extracts. African Journal of Traditional, Complementary and Alternative Medicines, 8(1).
[33]
S. Fishman & D. Teichera (2003).Challenges and choices in drug therapy for chronic pain. Cleveland Clinic journal of medicine, 70(2), 119-140.
[34]
U. Ghias, R. Abdur, R. Taj, & Q Muhammad (2011). Screening of Pisticia Chinensis Var. Intergerrima. Middle - East Journal of scientific Research. 7: 707-711.
[35]
V. Scheid (2007). Currents of tradition in Chinese medicine, Seattle: Eastland Press.
[36]
Y. Ho, F. Seow-Choen (2000). Randomized Clinical trial of micronized flavanoids in the Early control of bleeding from acuteinternal Hemorrhoids. British Journal of Surgery. 87: 1732-1733.
[37]
Z. Parveen, Y. Deng, M. Saeed, R. Dai, W. Ahmad and H. Yu (2007) Analgesic and anti-inflammatory activities of Thesium Chinese Extracts and major flavanoids Kaepherol and Kaempferol -3- Glucoside. Yakugako Zaashi.127: 1275 -1279.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186