Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer
Science Journal of Chemistry
Volume 1, Issue 1, April 2013, Pages: 1-6
Received: Mar. 16, 2013; Published: Apr. 2, 2013
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Ayman M. F. Elgohary, Department of medical laboratories College of Applied Medical Science, Majmaah University, Almajma’ah 11952, KSA
E. M. Ezz El-Arab, National Organization For Drug Control & Research, Pharmaceutical Chemistry Division, Giza, Egypt
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A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL
Pyrido[2,3-D][1,3]Oxazin-4-One, 2-Propylpyrido[2,3-D]Pyrimidin-4(3h)-One, Antitumor
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Ayman M. F. Elgohary, E. M. Ezz El-Arab, Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer, Science Journal of Chemistry. Vol. 1, No. 1, 2013, pp. 1-6. doi: 10.11648/j.sjc.20130101.11
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