Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1)
American Journal of Life Sciences
Volume 1, Issue 3, June 2013, Pages: 130-135
Received: Jun. 4, 2013;
Published: Jun. 30, 2013
Views 3002 Downloads 154
Amani Nour El-Din Abd El-Latif, Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt
Sahar Mohamed Elsheikh, Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt. (Corresponding author); Oral Pathology, Faculty of Dentistry. Alexandria Egypt
Hashem Mohamed Hassouna, Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt. (Corresponding author); L Oral Maxillofacial surgery, Faculty of Dentistry, Pharos University in Alexandria, Egypt
Odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma are the most common forms of cystic lesions and tumors that affect the jaw bones region. Demographic profiles of these lesions have been reported in various age groups in several countries, however, few reports can be found among Egyptian population. The purpose of this study is to evaluate the prevalence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in patients seeking treatment in Faculty of Dentistry of Alexandria and Pharos Universities, Alexandria, Egypt in the last four years (2009-2012).To study odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma clinically and histopathologically as well as to detect the immunoexpression of laminin-1. A clinical and a retrospective survey were carried out. For immunostaining, sections were immunostained with anti-laminin-1 primary antibody (#RB-082-A) according to manufactures, instructions. Statistical analysis was carried out on the tabulated data using (SPSS 16.0) software. It was found that the incidence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in male is slightly more than that in female, and the mandible was the most frequent affected side. Keratocystic odontogenic tumors and unicystic ameloblastoma were considered the most prevalent odontogenic tumors with an increase in the incidence of ameloblastic carcinoma in the last four years. The benign nature of some odontogenic cysts and the aggressive behavior of others could be explained by the expression of laminin-1 that may indicate that it might be valuable markers for the prediction of the biologic behavior of cystic lesions.
Amani Nour El-Din Abd El-Latif,
Sahar Mohamed Elsheikh,
Hashem Mohamed Hassouna,
Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1), American Journal of Life Sciences.
Vol. 1, No. 3,
2013, pp. 130-135.
B. G. Koseoglu, B. Atalay and M. A. Erdem, "Odontogenic Cysts: a Clinical Study of 90 Cases," Journal of Oral Science, vol. 46, No. 4, 2004, pp. 253-257.
F. Selvi1, M. S. Tekkesin, S. Cakarer 1, S. C. Isler1 and C. Keskin, "Keratocystic odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNORLabelling," Int J Med Sci 2012; 9(4):262-268. doi:10.7150/ijms.4243
J. A. Regezi, "Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws," Mod Pathol, vol. 15, No. 3, 2002, pp. 331-341
S. L. Avon, J. McComb and C. Clokie, "Ameloblastic carcinoma: Case report and literature review," J Can Dent Assoc Vol. 69, 2003, 573-576.
S. Poomsawat, J. Punyasingh and W. Weerapradist, "Expression of Basement Membrane Components in Odontogenic Cysts," Oral Diseases, Vol. 12, 2006, pp. 290-296.
M. S. Ayoub, H. M. Baghdadi and M. El-Kholy, "Immunohistochemical Detection of Laminin-1 and Ki-67 in Radicular Cysts and Keratocystic odontogenic Tumors," BMC Clinical Pathology, vol. 11, 2011, pp. 4
A. de Arcangelis, O. Lefebvre, A. Mechine-Neuville, C. Arnold, A. Kline and L. Remy, "Overexpression of Laminin Alpha1 Chain in Colonic Cancer Cells Induces an Increase in Tumor Growth," Int J Cancer, vol. 94, 2001, pp. 44-53.
S. Nuñez-Urrutia, R. Figueiredoand C. Gay-Escoda, "Retrospective Clinicopathological study of 418 odontogeniccysts," Med Oral Patol Oral Cir Bucal," vol. 15, 2010, pp. e767-773.
L. B. de Souza, M. A. Gordón-Núñez, C. F. Nonaka, M. C. de Medeiros, T. F. Torres and G. B. Emiliano, "Odontogeniccysts: Demographic Profile in a Brazilian Population Over a 38-Year Period," Med Oral Patol Oral CirBucal, vol. 15, 2010, pp. e583-590.
A. Açikgöz, E. Uzun-Bulut, B. Özdenand K. Gündüz, "Prevalence and Distribution of Odontogenic and NonodontogenicCysts in a Turkish Population," Med Oral Patol Oral Cir Bucal, vol. 17, No. 1, 2012, pp. e108-115.
M. A. Tawfik and M. M. Zyada, "Odontogenic Tumors in Dakahlia, Egypt: Analysis of 82 Cases," Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology," vol. 109, No. 2, 2010, pp. e67-e73.
R. A. Cawson, E. W. Odell and S. Porter, "Cawson` Essentials of Oral Pathology and Oral Medicine," 7thed, Churchill Livingstone, Edinburgh, 2002, pp. 102-121.
J. A. Regezi, J. J. Sciubba, R. C. K. Jordan, "Oral Pathology: Clinical Pathologic Correlations," 4thed, WB Saunders, St Louis, 2003, 241-254.
A. B. Bataineh, M. A. Rawashdeh and M. A. Al Qudah, "The Prevalence of Inflammatory and Developmental Odontogenic Cysts in a Jordanian Population: a Clinicopathologic Study," Quintessence Int, vol. 35, No. 10, 2004, pp. 815-819.
V. Ebenezer and B. Ramalingam, "A Cross-Sectional Survey of Prevalence of OdontogenicTumours," J Maxillofac Oral Surg, vol. 9, No. 4, 2010, 369-374.
R. S. Ramesh, S. Manjunath, T. H. Ustad, S. PaisandK. Shivakumar, Unicysticameloblastoma of the mandible - an unusual case report and review of literature Head & Neck Oncology vol. 2, 2010, p.1
R. Datta, J. S. Winston, G, Diaz-Reyes, T. R. Loree, L. Myers, M. A. Kuriakose, et al, "Ameloblastic Carcinoma: Report of an Aggressive Case with Multiple Bony Metastases," Am J Otolaryngol, vol. 24, 2003, pp. 64-69.
P. Ekblom, P, Lonai, J. F. Talts, "Expression and Biological Role of Laminin-1. Matrix Biol," vol. 22, No. 1, 2003, pp. 35-47.
S. Poomsawat, J. Punyasingh and P. Vejchapipat, Expression of basement membrane components in odontogenic tumors Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology vol. 104, No. 5, 2007, pp 666-675.
P. Lapthanasupkul, S. Poomsawat and J. Chindasombatjaroen, "Investigation of Basement Membrane Proteins in a Case of Granular Cell Ameloblastoma," International Journal of Oral Science, vol. 4, 2012, pp 45-49.
S. C. A. Gurgel, G. E. A. Ramos, A. L. Melo, B. C. Schlaepfer, R. O. de Souza, C. M. Oliveira and J. N. dos Santos, "Immunolocalisation of laminin-1 in Keratocystic odontogenic tumors," ActaHistochem, vol. 112, No. 6, 2010, pp. 624-629.
H. H. Araújo,R. José, , V. Thiago, L.M.Guedes, É.J.Dantas, Glandular odontogenic cyst: case report and review of diagnostic criteria, Journal of Cranio-Maxillofacial Surgery, vol. 40, No. 2, 2012, pp e46–e50.
P.Aggarwal, S.Saxena. Aggressive growth and neoplastic potential of dentigerous cysts with particular reference to central mucoepidermoid carcinoma. Br J Oral MaxillofacSurg, vol. 49, No. 6, 2011, pp e36-9