Effects of Neurotensin and LANT-6 on Food Intake in Chicks
American Journal of Life Sciences
Volume 3, Issue 3-2, May 2015, Pages: 17-23
Received: Mar. 20, 2015; Accepted: Mar. 24, 2015; Published: May 6, 2015
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Authors
Keiko Masuda, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan
Eiko Iwakoshi-Ukena, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan
Tetsuya Tachibana, Faculty of Agriculture, Department of Agrobiological Science, Ehime University, Matsuyama, Japan
Kazuyoshi Ukena, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan
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Abstract
Neurotensin (NT) and an NT-related peptide (Lys, Asn, NT8–13; LANT-6) are produced in the chicken brain and intestine, and these peptides are encoded by the same precursor gene (NT/LANT-6 precursor). Although it has been reported that the central administration of NT suppresses food intake in mammals, the effect of NT and LANT-6 on feeding behavior in birds has not yet been investigated. In this paper, we analyzed the expression levels of NT/LANT-6 precursor and the NT receptor (NTR1) mRNAs in the hypothalamic infundibulum, an important region for regulating feeding behaviors. We also examined the effects of NT and LANT-6 administration on food intake in chicks. Real-time PCR analysis showed that NT/LANT-6 precursor and NTR1 mRNAs had moderately high expression in the hypothalamic infundibulum. Further, in the hypothalamic infundibulum, the mRNA level of NT/LANT-6 precursor showed a trend toward increasing during postnatal development and increased 2.9-fold after a 48 hour fast, although the NTR1 mRNA level was not changed in both analyses. Contrary to our expectations, central administration of NT or LANT-6 had no effect on food intake in chicks.
Keywords
Brain, Chicken, Food Intake, Hypothalamic Infundibulum, LANT-6, mRNA, Neurotensin
To cite this article
Keiko Masuda, Eiko Iwakoshi-Ukena, Tetsuya Tachibana, Kazuyoshi Ukena, Effects of Neurotensin and LANT-6 on Food Intake in Chicks, American Journal of Life Sciences. Special Issue: Biology and Medicine of Peptide and Steroid Hormones. Vol. 3, No. 3-2, 2015, pp. 17-23. doi: 10.11648/j.ajls.s.2015030302.14
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