Physiological Functions and Pathology of Ghrelin
American Journal of Life Sciences
Volume 3, Issue 3-2, May 2015, Pages: 8-16
Received: Mar. 25, 2015; Accepted: Apr. 3, 2015; Published: May 6, 2015
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Authors
Takahiro Sato, Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Japan
Kanae Oishi, Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Japan
Takanori Ida, Division for Searching and Identification o Bioactive Peptides, Department of Bioactive Peptides, Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan
Masayasu Kojima, Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Japan
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Abstract
Ghrelin is a peptide hormone made up of 28 amino acid residues; the N-terminal serine 3 residues is modified by octanoic acid, a medium-chain fatty acid. Ghrelin is mainly secreted by the stomach and has various effects, including growth hormone release, hyperphagia, lipid accumulation, suppression of insulin secretion, and hypotensive effects. Most of these physiological effects are indispensable functions for the maintenance of homeostasis and contribute to the onset and promotion of metabolic syndrome. Accordingly, it is important to combine etiological and pathological understanding based on the biochemistry and physiology of ghrelin, which has a characteristic structure. In this manuscript, after presenting biochemical information on ghrelin, we provide an outline of its physiological function.
Keywords
Ghrelin, Ghrelin-O-Acyltransferase, Appetite
To cite this article
Takahiro Sato, Kanae Oishi, Takanori Ida, Masayasu Kojima, Physiological Functions and Pathology of Ghrelin, American Journal of Life Sciences. Special Issue:Biology and Medicine of Peptide and Steroid Hormones. Vol. 3, No. 3-2, 2015, pp. 8-16. doi: 10.11648/j.ajls.s.2015030302.13
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