Metabolic and Morphological Changes in Rats’ Eye after 7-Days Microgravity Simulation
American Journal of Life Sciences
Volume 3, Issue 1-2, January 2015, Pages: 18-24
Received: Nov. 24, 2014;
Accepted: Nov. 26, 2014;
Published: Dec. 27, 2014
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Margarita Vyalkina, Lab of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia
Anatoly Fedorov, Lab of the Fundamental Investigations in Ophthalmology, Research Institute of Eye Diseases, Moscow, Russia
Erika Eskina, Ophthalmological Department of Federal Medical-Biology Agency of Russia, Sphere Eye Clinic, Moscow, Russia
Yulia Medvedeva, Lab of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia
Elena Arkhipova, Lab of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia
Marina Lebedeva, Lab of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia
Nadezhda Khlebnikova, Lab of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia
Mikhail Baranov, Experimental Clinical Dept., Research Institute for Space Medicine, Federal Biomedical Agency of Russia, Moscow, Russia
Mikhail Karganov, Lab of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia
Microgravity simulation in rats resulted to changes in eye lavage content. Molecular subfraction analysis with laser correlation spectroscopy revealed significant differences in the pattern of particle distribution in five intervals: 1.9 -2.56 nm, 4.64-6.25 nm, 91.3 nm, 165-300 nm, and 400-734 nm. Microgravity modeling induced a series of interrelated processes in the retina of experimental rats manifesting in decreasing of total and layer-by-layer thickness of the retina, mild edema, and consequently, the increasing of specific density of neurons. In the inner nuclear layer, the cell density decreased because of the amacrine and bipolar cells. These changes could be explained by relative ischemia of the retinal layers, which are dependent on the retinal vessels circulation system.
Metabolic and Morphological Changes in Rats’ Eye after 7-Days Microgravity Simulation, American Journal of Life Sciences. Special Issue:Space Flight Factors: From Cell to Body.
Vol. 3, No. 1-2,
2015, pp. 18-24.
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