Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.
American Journal of Life Sciences
Volume 2, Issue 6-1, November 2014, Pages: 11-15
Received: Aug. 12, 2014; Accepted: Sep. 3, 2014; Published: Sep. 17, 2014
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Authors
Hafizur Rahman, Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Vijaya Badra Reddy, Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Soumya Ghosh, Department of Microbiology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Sandeep Kumar Mistry, Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Geetika Pant, Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Sibi G., Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
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Abstract
Methanolic flower extracts of Plumeria alba and P. rubra were tested for in vitro antioxidant potential, cytotoxicity and hypolipidemic activities. DPPH assay of methanolic extract of Plumeria revealed that 81% and 72% inhibition by P. alba and P. rubra respectively and the total phenolic content was found as 173.9 µg ml-1 and 167.3 µg ml-1. Significant free radical scavenging activities of 1.74 mg ml-1and 1.67 mg ml-1 were observed due to the higher phenolic content. Anti-chlolesterol assay of the extracts demonstrated P. rubra has highest hypolipidemic activity (60%) followed by P. alba (52%). MTT assay using HCT 116 cell lines revealed the antiproliferative and cytotoxic activities of P. alba with an IC50 value of 259.9 µg ml-1. Plumeria species could be a new source of drugs for the treatment of colon cancer and hyperlipidemic conditions due to higher antioxidant potential and phenolic content which was revealed from the study.
Keywords
Plumeria, Antioxidant, Anticancer, Anti-Cholesterol, Colon Cancer
To cite this article
Hafizur Rahman, Vijaya Badra Reddy, Soumya Ghosh, Sandeep Kumar Mistry, Geetika Pant, Sibi G., Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L., American Journal of Life Sciences. Special Issue: Recent Developments in Health Care through Plants and Microbes. Vol. 2, No. 6-1, 2014, pp. 11-15. doi: 10.11648/j.ajls.s.2014020601.13
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