Analysis of the Levels of Endothelin, Homocysteine and Blood Lipid in Patients with Clinical and Subclinical Hyperthyroidism
American Journal of Life Sciences
Volume 7, Issue 1, February 2019, Pages: 27-30
Received: Feb. 26, 2019;
Published: Apr. 28, 2019
Views 495 Downloads 87
Xu Qian, Department of Medical Technology of Cangzhou Medical College, Cangzhou, China; Cangzhou Thyroid Disease Engineering Research Center, Cangzhou, China
Zhang Jing-yu, Laboratory Department of Cangzhou Hospital Integrated of Chinese and Western Medicine, Cangzhou, China
Li Hong-yan, Department of Medical Technology of Cangzhou Medical College, Cangzhou, China; Cangzhou Thyroid Disease Engineering Research Center, Cangzhou, China
Hou Jian-zhang, Cangzhou People's Hospital, Cangzhou, China
[Objective] To discuss the changes of endothelin (ET), homocysteine (Hcy) and blood lipids levels in patients with hyperthyroidism and subclinical hyperthyroidism, and to explore their clinical significance. [Methods] The authors choose 251 cases of hyperthyroidism, 242 cases of subclinical hyperthyroidism and 130 cases of the control group to test ET, Hcy, TC, TG, HDL, LDL and LPa. [Results] The level of ET of Hyperthyroidism group is higher than subclinical hyperthyroidism group and the control group. The level of ET of subclinical Hyperthyroidism group is higher than the control group(P<0.05). The level of Hcy of Hyperthyroidism group and subclinical Hyperthyroidism group was lower than the control group(P<0.05). The level of TG, TC, LDL, LPa of subclinical Hyperthyroidism group are lower than the control group(P<0.05). The level of TG, TC, HDL, LDL, LPa of Hyperthyroidism group are lower than the control group and subclinical hyperthyroidism group (P<0.05). [Conclusions] All of ET, Hcy and lipids participate in the occurrence and development process of hyperthyroidism and subclinical hyperthyroidism. Monitoring the change of related indexes is helpful to predict the transformation of subclinical hyperthyroidism to hyperthyroidism and the occurrence of cardiovascular disease.
Analysis of the Levels of Endothelin, Homocysteine and Blood Lipid in Patients with Clinical and Subclinical Hyperthyroidism, American Journal of Life Sciences.
Vol. 7, No. 1,
2019, pp. 27-30.
Su Jun-ping, Zhang-Bo, Liu Chun-yan, et al. Changes in levels of thyroid hormone osteometabolism-related cytokines and bone metabolism-related indicators in hyperthyroidism patients and their clinical significance [J]. Shanxi Medical Journal, 2017, 46 (4):413-415.
Hou Zhen-jiang, Zhang Jing-yu, Bian Yun-zhuo, et al. Changes of serum lipid level, its ratio and cystatin C level in patients with hyperthyroidism and subclinical hyperthyroidism [J]. Shandong Medical Journal, 2017, 57(39):91-93.
Chen-Hua, Xin-Ning. Clinical efficacy and changes in serum lipid index of levothyroxine in subclinical and clinical hypothyroidism [J]. Chinese Journal of Clinical Research, 2014, 6 (9):84.
Guo Ya-qing, Wei Xi-liang, Zhao Dan-ning, et al. Plasma endothelin and carbon monoxide levels in patients with subclinical hypothyroidism [J]. China Journal of Modern Medicine, 2011, 21 (11):1407-1409.
Zhou Yan-guo, Mai Rui-lin, Huang Min-xuan, et al. Effects of alprostol on plasma endothelin, homocysteine and coagulation function in patients with coronary heart disease [J]. Hainan Medical Journal, 2018, 29(07):917-919.
Pancotto TE, Rossmeisl JH, Huckle WR, et al. Evaluation of endothelin-1 and MMPs-2, -9, -14 in cerebrospinai fluid as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism [J]. Res Vet Sci, 2016, 105:115-120.
Li Ying-hui, Li-Jun, Ren Si-ying, et al. Effects of rosiglitazone on the expression of endothelin-1 around the lesion and the permeability of blood-brain barrier in rabbits with cerebral hemorrhage [J]. Neural Injury and Functional Reconstruction, 2018, 13(03):109-112.
Chen Xue-hui, Yin Qing-feng, Wang-Tao, et al. Changes of important plasma factors in radionuclide iodine therapy for hyperthyroidism heart disease [J]. Medical Recapitulate, 2013, 19(13):2492-2494.
Chai Guo-lu, Tan Li-yan, Yang Yu-hong, et al. Changes of plasma endothelin and nitric oxide levels in patients with hyperthyroidism and their clinical significance [J]. Heilongjiang Medicine and Pharmacy, 2004(04):34-35.
Hu Yao-shi, Zeng Zhi-yu. Research Progress on the Relationship between Homocysteine and Common Clinical Diseases [J]. Chinese Journal of New Clinical Medicine, 2017, 10(08):811-815.
Mao-Lei, Geng Guo-ying, Zhao Ming-hu, et al. Effects of rosuvastatin on serum levels of high-sensitivity C-reactive protein and homocysteine in patients with acute coronary syndrome [J]. Clinical Research, 2018(06):84-85.
Liu Xiang-ru, Li-Yue, Yang-Bin, et al. Analysis of plasma homocysteine level and related factors in patients with type 1 and type 2 diabetes mellitus [J]. Contemporary Chinese Medicine, 2018(14):1-2.
Min JY, Min KB. The Folate-Vitamin B12 Interaction, Low Hemoglobin, and the Mortality Risk from Alzheimer’s Disease [J]. J Alzheimers Dis, 2016, 52 (2):705-712.
Wang Xiao-quan, Wang Zu-sen, Shen Yu-hua, et al. Study on the correlation between serum homocysteine level and P300 in late-onset depression [J]. Journal of Psychiatry, 2017, 30(06): 410-412.
Pan Da-fu, Zhang Li-juan, Ren Yue-zhong. Study on plasma homocysteine level and MTHFR gene polymorphism in patients with hyperthyroidism and hypothyroidism [J]. Chinese Journal of Endocrinology and Metabolism, 2004(02):36-37.
Dai Li-li, Liu Jia-jia, Mi Yu-jing et al, Study on the correlation between subclinical thyroid dysfunction and serum resistin and homocysteine [J]. Chinese Journal of Health laboratory Technology, 2015, 25(14):2346-2348.
Wu Zai-rong, Zhang Li-rong, Pan Yu-qin, et al. Clinical significance of serum homocysteine and lipid levels in patients with thyroid dysfunction [J]. Progress in Modern Biomedicine, 2009, 9 (22): 4276-4278.
Xiao-Lin, Guo-Mei, Fan Ruiyun. The relationship between thyroid hormone levels and lipid metabolism in hyperthyroidism [J]. Chinese Journal of Laboratory diagnosis, 2016, 20(10):1679-1681.
Tan-Qian. Clinical analysis of abnormal metabolism of blood sugar and lipid in patients with hyperthyroidism and hypothyroidism [J]. Capital Food Medicine, 2018, 25(09):19.
Yuan-Zhuo. Metabolism of blood lipid and blood sugar in patients with abnormal thyroid function during pregnancy [J]. Maternal and Child Health Care of China, 2017, 32 (9):1874-1876.
Gu-Qing, Shao Ke-ke, Wang Yun-xia. Analysis of lipid and serum protein levels in patients with thyroid dysfunction [J]. Laboratory Medicine and Clinic, 2014, 11(24):3455-3456.
Duan Wen-bing, Liu-Yun, Zhang Lu-lu, et al. Correlation analysis of blood lipid, HCY, blood routine and indexes of thyroid function in patients with subclinical thyroid dysfunction [J]. Journal of New Medicine, 2018, 49 (1): 42-46.