Antioxidant and Antidiabetic Properties of Vitex nigundo L. Leaves
American Journal of Life Sciences
Volume 5, Issue 1, February 2017, Pages: 21-26
Received: Dec. 25, 2016; Accepted: Jan. 10, 2017; Published: Mar. 6, 2017
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Authors
Most. Fatimatuz Zahura Falguni, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
Md. Amirul Islam, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
Md. Mahmudul Hasan, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
S. M. M. Mahmud Hossain Mousum, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
Md. Ashraduzzaman, Department of Chemistry, Rajshahi University of Engineering and Technology, Rajshahi, Bangladesh
Shahanaz Khatun, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
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Abstract
Vitex Nigundo Linn. is credited with important medicinal activities such as antioxidant, anti-inflammatory, analgesic, anticonvulsant etc. The purpose of the presents study was to assess the therapy effect of V. Nigundo leaves extract on glucose level, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, SGPT and SGOT in blood serum of diabetic animals. Ethyl alcohol extract of V. Nigundo leaves in doses of 200 and 300 mgkg-1 body weights was daily administered orally by gavages to mice for 21 days to evaluate their antihyperglycemic and antihyperlipidemic effects on normal and streptozotocin-induced diabetic mice. Ethyl alcohol extract of V. Nigundo leaves in doses of 300 mgkg-1 body weights showed (P<0.01) more significant activity than the ethyl alcohol extract of V. Nigundo leaves in doses of 200 mgkg-1 body weights. The study validates scientifically the widely claimed use of V. Nigundo leaves as an ethnomedicine to treat diabetes mellitus.
Keywords
Vitex nigundo, Antidiabetic, Diabetes Mellitus, Hyperglycemic, Hyperlipidemic
To cite this article
Most. Fatimatuz Zahura Falguni, Md. Amirul Islam, Md. Mahmudul Hasan, S. M. M. Mahmud Hossain Mousum, Md. Ashraduzzaman, Shahanaz Khatun, Antioxidant and Antidiabetic Properties of Vitex nigundo L. Leaves, American Journal of Life Sciences. Vol. 5, No. 1, 2017, pp. 21-26. doi: 10.11648/j.ajls.20170501.14
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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