Please enter verification code
Special Issues
Phytoecdysteroids: Isolation and Biological Applications
American Journal of Life Sciences
Volume 5, Issue 1, February 2017, Pages: 7-10
Received: Dec. 21, 2016; Accepted: Jan. 23, 2017; Published: Feb. 24, 2017
Views 4663      Downloads 223
Yahya Al Naggar, Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt
Mohamed Ghorab, Environmental Toxicology Lab, Central Laboratories Unit, National Institute of Oceanography and Fisheries (NIOF), Alexandria, Egypt; Department of Animal Science, Wildlife Toxicology Laboratory, Michigan State University, East Lansing, MI, USA
Kariman Mohamed, Plant Protection Department, Faculty of Agriculture, Suez Canal University, Ismailia, Egypt
Article Tools
Follow on us
Phytoecdysteroids are analogues of arthropod steroid hormones found in plants, where they deter predation by non-adapted predators. Their discovery in several plant species displayed a wide array of rather beneficial agricultural impact. An overview is given on both well-known and recently discovered phytoecdyteroids including a sophisticated isolation scheme and notable physiological and pharmacological effects of ecdysteroids on vertebrates.
Ecdysteroides, Plants, Application, Phytochemistry, Extraction
To cite this article
Yahya Al Naggar, Mohamed Ghorab, Kariman Mohamed, Phytoecdysteroids: Isolation and Biological Applications, American Journal of Life Sciences. Vol. 5, No. 1, 2017, pp. 7-10. doi: 10.11648/j.ajls.20170501.12
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Adler, J. H., & Grebenok, R. J. (1995). Biosynthesis and distribution of insect-molting hormones in plants—a review. Lipids, 30(3), 257-262.
Changrakala MV, Maribashetty VG, Jyothi HK. 1998. Application of phytoecdysteroids in sericulture. Curr Sci (India) 74:341–346.
Davies, T. G., Lockley, W. J., Boid, R., Rees, H. H., & Goodwin, T. W. (1980). Mechanism of formation of the A/B cis ring junction of ecdysteroids in Polypodium vulgare. Biochemical Journal, 190(3), 537-544.
Dinan L, Harmatha J, Volodin V, Lafont R. 2009. Phytoecdysteroids: diversity, biosynthesis and distribution. In: Smagghe G, editor. Ecdysone: structures and functions. New York: Springer Science. p 3–45.
Dinan L. 2001, Phytoecdysteroids: biological aspects. Phytochemistry 57:325-339.
Fomovska GN, Berdyshev AG, Kholodova YD. 1992. Immunomodulatory effect of ecdysteroids. Ukrain Biokhim Zh 64:56–61.
Gao XY, Wang DW, Li FM 2000, Determination of ecdysterone in Achyranthes bidentata Bl. and its activity promoting proliferation of osteoblast-like cells. Yao Xue Xue Bao 35(11):868-870.
Gilbert LI, Rybczynski R, Warren JT 2002, Control and biochemical nature of the ectysteroidogenic pathway. Annual Review of Entomology 47: 883-916
Grebenok, RJ et al 1994, Biosynthesis of ecdysone and ecdysone phosphates in spinach. Phytochemistry 36:1399-1408.
Kamba M et al 1994, 22-deoxy-20-hydroxyecdysone and its phosphoric ester from ovaries of the silkworm, Bombyx mori. Insect Biochem Molec Biol 24:395-402.
Kanazawa A, Tanaka N, Kashiwada K. 1972. Nutritional requirements of prawns-IV. The dietary effect of ecdysones. Bull Jap Soc Sci Fish 38:1067–1071.
Kholodova YD. 2001. Phytoecdysteroids: biological effects, application in agriculture and complementary medicine. Ukr Biokhim Zh 73:21–29.
Kosar K, Opletal L, Vokac K, Harmatha J, Sovova M, Cerovsky J, Kratky F, Dvorak J. 1997. Embryotoxicity of 20-hydroxyecdysone and polypodine B from Leuzea carthamoides DC. Pharmazie 52:406–407.
Kosovsky MI, Syrov VN, Mirakhmedov MM, Katkova SP, Khushbaktova ZA. 1989. The effect of nerobol and ecdysterone on processes related to insulin regulatory function in normal and in experimental insulin resistance. Probl Endokrinol 35:77–81.
Kutepova TA, Syrov VN, Khushbaktova ZA, Saatov Z. 2001. Hypoglycemic activity of the total ecdysteroid extract from Ajuga turkestanica. Pharm Chem J 35:608–609.
Lafont R, Dinan L. 2009. Innovative and future applications for ecdysteroids. In: Smagghe G, editor. Ecdysone: structures and functions. New York: Springer Science. p 551–578.
Lupien PJ, Hinse C, Chaudhary KD. 1969. Ecdysone as a hypocholesterolemic agent. Arch Int Physiol Biochim 77:206–212.
Otaka T, Uchiyama M, Okui S, Takemoto T, Hikino H, Ogawa S, Nishimoto N. 1968. Stimulatory effect of insect metamorphosing steroids from Achyranthes and Cyathula on protein synthesis in mouse liver. Chem Pharm Bull 16:2426–2429.
Sakhibov AD, Syrov VN, Usmanova AS, Abakumova OY. 1989. Experimental analysis of the immunotropic action of phytoecdysteroids. Dok Akad Nauk Uzbek SSR (8) 55–57.
Schmelz, E. A., Grebenok, R. J., Ohnmeiss, T. E., & Bowers, W. S. (2002). Interactions between Spinacia oleracea and Bradysia impatiens: a role for phytoecdysteroids. Archives of insect biochemistry and physiology, 51(4), 204-221.
Sla´ma K, Lafont R. 1995. Insect hormones: ecdysteroids: their presence and actions in vertebrates. Eur J Entomol 92:355–377.
Song CQ & RS Xu 1991, Phytoecdysones from the roots of Tinospora capillipes. Chinese Chemical Letters 2(1):13-14.
Soriano, I. R., Riley, I. T., Potter, M. J., & Bowers, W. S. (2004). Phytoecdysteroids: a novel defense against plant-parasitic nematodes. Journal of chemical ecology, 30(10), 1885-1899.
Syrov VN, Khushbaktova ZA, Abzalova MK, Sultanov MB. 1983. On the hypolipidemic and antiatherosclerotic action of phytoecdysteroids. Dok Akad Nauk Uzbek SSR (9) 44–45.
Syrov VN, Khushbaktova ZA, Tashmukhamedova MA. 1997. Hypoglycemic action of phytoecdysteroids and some aspects of its mechanism of realization in experimental animals. Dok Akad Nauk Resp Uzbek (4) 46–49.
Syrov VN, Nabiev AN, Sultanov MB. 1986b. The effect of phytoecdysteroids on the bile secretion function of the liver in normal rat and animals with experimental hepatitis. Farmakol Toksikol 49:100–103.
Trenin DS, Volodin VV. 1999. 20-Hydroxyecdysone as a human lymphocyte and neutrophil modulator: in vitro evaluation. Arch Insect Biochem Physiol 41:156–161.
Yoshida T, Otaka T, Uchiyama M, Ogawa S. 1971. Effect of ecdysterone on hyperglycemia in experimental animals. Biochem Pharmacol 20:3263–3268.
Zhang YH, Cheng JK, Yang L et al 2002, Triterpenoids from Rhaponticum uniflorum. Journal of the Chinese Chemical Society 49:117-124.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186