Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats
American Journal of Life Sciences
Volume 3, Issue 3, June 2015, Pages: 203-212
Received: May 9, 2015; Accepted: May 15, 2015; Published: May 27, 2015
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Charles Obiora Nwonuma, Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria
Emenike Onyebum Irokanulo, Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria
Adeyemi Eunice Jolaiya, Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria
Ayokanmi Ore, Biochemistry Unit, Department of Chemical Sciences, Faculty of Natural Sciences, Ajayi Crowther University, Oyo, Oyo State, Nigeria
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This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.
Annona senegalensis, Testes, Testicular Function, Histopathology, Rat
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Charles Obiora Nwonuma, Emenike Onyebum Irokanulo, Adeyemi Eunice Jolaiya, Ayokanmi Ore, Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats, American Journal of Life Sciences. Vol. 3, No. 3, 2015, pp. 203-212. doi: 10.11648/j.ajls.20150303.21
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