Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice
American Journal of Life Sciences
Volume 3, Issue 2, April 2015, Pages: 62-70
Received: Jan. 25, 2015; Accepted: Feb. 11, 2015; Published: Feb. 16, 2015
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Authors
Ebtehal M. Farrag, Therapeutic Chemistry Department, National Research Center, Dokki, Egypt
Azza M. Mohamed, Therapeutic Chemistry Department, National Research Center, Dokki, Egypt; Biochemistry Department, Faculty of Science for Girl's, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
Shadia M. Kadry, Zoology Department, Women's College for Arts, Science and Education, Ain Shams University, Cairo, Egypt
Ahlam H. Mahmoud, Therapeutic Chemistry Department, National Research Center, Dokki, Egypt; Biology Department, Faculty of Science for Girl's, Jazan University, Jazan, Kingdom of Saudi Arabia
Abdel-Razik H. Farrag, Pathology Department, National Research Center, Dokki, Egypt
Dalia B. Fayed, Therapeutic Chemistry Department, National Research Center, Dokki, Egypt
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Abstract
Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin- 10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection.
Keywords
Schistosoma Mansoni- Chloroform Extract of Citharexylum Quadrangular Leaves- Micronutrients
To cite this article
Ebtehal M. Farrag, Azza M. Mohamed, Shadia M. Kadry, Ahlam H. Mahmoud, Abdel-Razik H. Farrag, Dalia B. Fayed, Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice, American Journal of Life Sciences. Vol. 3, No. 2, 2015, pp. 62-70. doi: 10.11648/j.ajls.20150302.12
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