Ex-Vivo Anti-Inflammatory and Antimicrobial Activities of the Leaves of Bauhinia acuminata
American Journal of Life Sciences
Volume 2, Issue 5, October 2014, Pages: 267-270
Received: Sep. 14, 2014;
Accepted: Sep. 20, 2014;
Published: Oct. 20, 2014
Views 3620 Downloads 232
Md. Reyad-Ul-Ferdous, Department of Pharmacy, Progati Medical Institute, Dhaka-1207, Bangladesh; Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh
Sayma Akhter, Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh
Md. Zahirul Islam Khan, Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh
Md. Eshak Khan, Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh
Md. Atiqul Islam, Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh
Md. Sharif Ullah, Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh
Follow on us
In present study, the methanol extracts and all fractions of leaves of Bauhinia acuminata were subjected to various biological screening such as membrane stabilizing activity and antimicrobial screening. This investigation suggested that, leaves of Bauhinia acuminata were highly effective in the membrane stabilizing activity as the extractives prevented the lysis of erythrocyte by hypotonic solution and heat induced. In hypotonic solution induced condition the highest membrane stabilizing activity was exhibited by the Pet ether soluble fraction (PESF-418.26%) followed by carbon tetra chlororide soluble fraction (CTCSF-418.26%). Significant amount of membrane stabilizing activity were also present in methanol soluble fraction (MESF-13.46%) and aqueous soluble fraction (AQSF-167.30%). On the other hand, heat induced condition the maximum membrane stabilizing activity was exhibited by the carbon tetra chlororide soluble fraction (CTCSF-853.3%) followed by Methanol soluble fraction (MESF-423.88%). Significant amount of membrane stabilizing activity were also present in Pet ether soluble fraction (PESF-81.77%) and aqueous soluble fraction (AQSF-40.46%). In this study, the antimicrobial activity, among all extractives of leaves of Bauhinia acuminate was found to be negligible.
Bauhinia Acuminate, Anti-Inflammatory, Antimicrobial Activity
To cite this article
Md. Zahirul Islam Khan,
Md. Eshak Khan,
Md. Atiqul Islam,
Md. Sharif Ullah,
Ex-Vivo Anti-Inflammatory and Antimicrobial Activities of the Leaves of Bauhinia acuminata, American Journal of Life Sciences.
Vol. 2, No. 5,
2014, pp. 267-270.
Verdcourt, B. 1979. A Manual of New Guinea Legumes. Office of Forests division of botany, Lae (Papua New Guinea). 645pp.
Howard, Richard A. 1988. Flora of the Lesser Antilles: Leeward and Windward Islands. Vol. 4, Dicotyledoneae-Part 1. Arnold Arboretum, Harvard University. 673 pp.
Sadipa nag, Anirban Paul, Ritu Parna Datta. Phytochemical analysis of methanolic extract of some medicinal plants. International Journals of scientific and research publications 2013; 3(4) p1648.
Van Wagenen, B.C., Larsen, R., Cardellina, J.H., Ran dazzo, D., Lidert, Z.C. and Swithenbank, C. 1993. Ulosantoin, a potent insecticide from the sponge Ulosa ruetzleri. J. Org. Chem. 58, 335-337.
Mounnissamy VM, Kavimani S, Balu V, Drlin QS: Evaluation of anti-inflammatory and membrane stabilizing properties of ethanol extract of Canjera rehedi. Iranian Journal of Pharmacology and Therapeutics 2008, 6:235-237.
Shinde UA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ and Saraf MN: Preliminary studies on the immunomodulatory activity of Cedrus deodara wood oil. Fitoterapia 1999; 70: 333-339.
Sikder MA, Rahman MA, Kaisar MA, Rahman MS, Hasan CM and Rashid MA: In vitro Antioxidant, reducing power, free radical scavenging and membrane stabilizing activities of seeds of Syzygium cumini L. Latin American Journal of Pharmacy 2011; 30: 781-5.
Reyad-ul-Ferdous M, Azam MG and Hossain MD: Phytochemical screening, in-vitro membrane stabilizing and thrombolytic activities of Lophopetalum javanicum. Int J Pharm Sci Res 2014; 5(2): 350-53.
Bauer AW, Kirbey WMM, Sherries JC, Truck M. Antibiotic susceptibility testing by standardized single disc method. Am J Clinical Pathol 1996; 45: 493- 496.
Chaitanya R, Sandhya S, David B, Vinod KR, Murali S: HRBC Membrane Stabilizing Property of Roor, Stem and Leaf of Glochidion velutinum. International Journal of Research in Pharmaceutical and Biomedical sciences 2011; 2(1):256-259.
Middleton E, Kandaswami C: Effect of flavonoids on immune and inflammatory cell function. Biochemical Pharmacology 1992; 43:1167-1179.
Read MA: Flavonoids: naturally occurring anti-inflammatory agents. American Journal of Pathology 1995; 147:235-237.
Oweyele B, Oloriegbe YY, Balaogun EA, Soladoye AO: Analgesis and anti-inflammatory properties of Nelsonia Canescens leaf extract. Journal of Ethnopharmacology 2005; 99:153-156.
Md. Reyad-ul-Ferdous, Mosharaf Hossen and Fazle Noor Biswas. In-vitro potential antimicrobial and antioxidant activities of Lablab niger leaves. International Journal of Pharma Sciences and Research 2014; 5(6): 257-261.