Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)
American Journal of Life Sciences
Volume 2, Issue 4, August 2014, Pages: 217-223
Received: Aug. 6, 2014; Accepted: Aug. 16, 2014; Published: Aug. 30, 2014
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Authors
Hend Mohamed Helmy, Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Egypt
Taissir Ali Omar, Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Egypt
Sahar Mohamed ElSheikh, Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Egypt
Ahmed Serag Habib, Department of Cranio Maxillofacial and Plastic Surgery, Faculty of Dentistry, Alexandria University, Egypt
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Abstract
Objectives: O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) and cigarette smoking. Study Design: MGMT protein expression in 22 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Correlation with detailed tobacco history was then tested by statistical analysis. Results: All the non smoker OSCC cases showed positive immunoexpression. However 3 cases of the smoker patient revealed a weak positive immunostaining with only sporadic cells at the periphery. Conclusion: The results suggest that the absence of MGMT expression is related strongly to tobacco smoking and, thus, might be a significant event in oral carcinogenesis.
Keywords
O6-Methylguanine-DNA Methyltransferase, Tobacco, Oral Squamous Cell Carcinoma
To cite this article
Hend Mohamed Helmy, Taissir Ali Omar, Sahar Mohamed ElSheikh, Ahmed Serag Habib, Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers), American Journal of Life Sciences. Vol. 2, No. 4, 2014, pp. 217-223. doi: 10.11648/j.ajls.20140204.15
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