Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice
American Journal of Life Sciences
Volume 2, Issue 4, August 2014, Pages: 205-210
Received: Aug. 4, 2014; Accepted: Aug. 11, 2014; Published: Aug. 20, 2014
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Authors
Marowa Mansour AlMathkour, College of Science, King Saud University, Riyadh, Saudi Arabia
Entissar Suliman AlSuhaibani, College of Science, King Saud University, Riyadh, Saudi Arabia
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Abstract
This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.
Keywords
Aspirin, Sperm Malformation, Radioprotection
To cite this article
Marowa Mansour AlMathkour, Entissar Suliman AlSuhaibani, Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice, American Journal of Life Sciences. Vol. 2, No. 4, 2014, pp. 205-210. doi: 10.11648/j.ajls.20140204.13
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