Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice
This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.
Marowa Mansour AlMathkour,
Entissar Suliman AlSuhaibani,
Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice, American Journal of Life Sciences.
Vol. 2, No. 4,
2014, pp. 205-210.
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