Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma
American Journal of Life Sciences
Volume 2, Issue 3, June 2014, Pages: 182-189
Received: Jun. 9, 2014; Accepted: Jun. 13, 2014; Published: Jun. 30, 2014
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Authors
Sahar Mohamed El-Sheikh, Professor of oral pathology, Faculty of dentistry, Alexandria University, Egypt
Amani Noureldin Abd El-Latif, Associatte professor of oral pathology, Faculty of dentistry, Pharos University, Alexandria, Egypt
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Abstract
Salivary gland tumors comprise a significant proportion of oral tumors. Maspin is a non-inhibitory serine protease inhibitor (serpin). It is supposed to suppress tumor-induced angiogenesis, tumor cell motility, invasion and metastasis. Objectives: To evaluate salivary gland tumors clinically, investigate the immunoexpression of maspin in mucoepidermoid and adenocystic carcinoma of the salivary gland tumors and to detect the correlation of maspin expression with biological behavior of these tumors.Materials and methods: Fourteen cases of malignant salivary gland tumors were retrieved from the Oral Pathology files of Faculty of Dentistry, Alexandria University, Egypt. The study included eight cases of mucoepidermoid carcinoma, six cases of adenoid cystic carcinoma. Two specimens of normal salivary tissue were taken as control.Results: The difference in mean optical density of maspin expression between low-grade and high-grade MEC was calculated. Optical density was higher in low-grade type compared to the high grade one with a significant difference (P< 0.05).Moreover, the results of this study showed difference between the MOD of adenoid cystic carcinoma subtypes, with the solid subtype expressing the lowest percentage. Conclusion: Maspin protein is overexpressed in low grade malignant salivary gland tumors, and decrease as the histological malignancy rises so it can be used as prognostic marker in salivary gland carcinoma. In addition, maspin could serve as a therapeutic target in salivary gland tumors including recombinant protein or gene therapy.
Keywords
Mucoepidermoid Carcinoma, Adenoid Cystic Carcinoma, Maspin
To cite this article
Sahar Mohamed El-Sheikh, Amani Noureldin Abd El-Latif, Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma, American Journal of Life Sciences. Vol. 2, No. 3, 2014, pp. 182-189. doi: 10.11648/j.ajls.20140203.18
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