Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients
International Journal of Immunology
Volume 3, Issue 2-1, March 2015, Pages: 8-20
Received: Jan. 14, 2015; Accepted: Jan. 19, 2015; Published: Feb. 7, 2015
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Authors
Oloke J. K., Department of Pure and Applied Biology, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Nigeria; Department of Microbiology & Immunology; All Saints University; Belair, Kingstown, St Vincent &The Grenadines
Adebayo E. A., Department of Pure and Applied Biology, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Nigeria; Biotechnology of Edible, Functional and Medicinal Mushrooms, Colegio de Postgraduados, Apartado Postal 129, Puela, Puebla, Mexico
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Abstract
In the recent years, mushrooms are distinguished as important natural resources of immunotherapy which can be used as immunomodulating and immunostimulating in the management of some immunodeficiency diseases such as cancer, tumour, HIV, tuberculosis etc. Mushroom of the genus Pleurotus are good sources of several bioactive compounds which are able to augment or complement a desired immune response. Such bioactive compounds are polysaccharopeptides, polysaccharide-proteins, functional proteins (ubiquinone-9, nebrodeolysin, ubiquitin-like peptide and glycoprotein), glucans, proteoglycans and many others. Most of these bioactive compounds follow the immunomodulatory pathway mechanism of polysaccharide (β-glucan) from mushrooms by stimulating activities for both innate and adaptive immune systems. They proliferate and activate innate immune system components such as natural killer (NK) cells, neutrophils, and macrophages, and stimulate cytokines expression and secretion. These cytokines in turn activate adaptive immunity through the promotion of B-cells for antibodies production and stimulation of T-cell differentiation to T helper (Th1 and Th2) cells, which mediate cell and humoral immunities, respectively. In this review, the immunotherapeutic potential of oyster mushroom in relation to bioactive compounds produced is shown and this suggests that the oyster mushrooms are one of the most important natural products and functional foods.
Keywords
Oyster Mushroom, Immunotherapy, Beta Glucan, Lectin, Polysaccharide
To cite this article
Oloke J. K., Adebayo E. A., Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients, International Journal of Immunology. Special Issue: Immunotherapy. Vol. 3, No. 2-1, 2015, pp. 8-20. doi: 10.11648/j.iji.s.2015030201.12
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