Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients
International Journal of Immunology
Volume 3, Issue 6, December 2015, Pages: 57-71
Received: Oct. 9, 2015; Accepted: Oct. 21, 2015; Published: Nov. 26, 2015
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Authors
Addisu Gize Yeshanew, Department of Microbiology, Immunology and Parasitology, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia
Afework Kassu Gizaw, Department of Microbiology, Immunology and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
Biniam Mathewos Tebeje, QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Public Health, University of Queensland, Brisbane, Australia; Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
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Abstract
The range of T cell abnormalities in advanced HIV-1 infection treatment is broad. The defects are both quantitative and qualitative and affect virtually every limb of the immune system. Beyond the precise measurement of naive T cells (CD45RA+CCR7+CD27+CD28+), the differential expression of different molecules on T cell allows the distinction between numerous subsets of resting or antigen-experienced T cells on the treatment. However, in spite of intense investigation, the mechanisms underlying highly active antiretroviral therapy (HAART) –induce immune reconstitution remain to be fully characterized. HAART treatment induced changes in the peripheral distribution of naïve (CD45RA+ CD62L+) and memory CD45RA- CD62L+) cells, CCR5, CXCR4-, CD95- expressing T cells, T-reg cells and on gamma delta (ϒδ) T cells. As a concluding remark prolonged suppression of plasma viral load ( pVL) by HAART improves not only ɑβ T-cell function but also ϒδ T-cell reactivity, and it is strongly recommended that once started the treatment, sever immunocompromized patient should continue the treatment for long time.
Keywords
T-lymphocytes, HIV-1 Infection, Highly Active Antiretroviral Therapy
To cite this article
Addisu Gize Yeshanew, Afework Kassu Gizaw, Biniam Mathewos Tebeje, Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients, International Journal of Immunology. Vol. 3, No. 6, 2015, pp. 57-71. doi: 10.11648/j.iji.20150306.11
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Copyright © 2015 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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