Personal Information
Lokendra Sharma

Center for Biological Sciences, Central University of Bihar, Patna, Bihar, India

Lokendra Sharma
, Ph.D. (Biochemistry)
Work Experiences
From 9/2007 to 7/2013, Post-Doctoral Fellow , The University of Texas Health Science Center at San Antonio, United States
From 7/2013 to 4/2014, Post-Doctoral Associate , Children's Hospital of Pittsburgh, United States
From 5/2014 to Present, Assistant Professor of Biotechnology , Central University of Bihar, India
From 2014 to 2017, Mitochondrial dysfunction in cancer progression , Funding Source: Department of Science and Technology, Government of India
Mitochondria, Oxidative stress, Metabolism, Cancer and Aging
Book Chapter: Meenakshi Tiwari, Lokendra K. Sharma, Madan M. Godbole. ENHANCEMENT OF CELL DEATH IN HIGH GRADE GLIOMA CELLS: ROLE OF N-(4-HYDROXYPHENYL) RETINAMIDE-INDUCED AUTOPHAGY Chapter 32, Four-volume series discussing AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Vol. 1, Molecular Mechanism, Chapter 16.
Journal Articles
c-Myc programs fatty acid metabolism and dictates acetyl CoA abundance and fate. J Biol Chem. 2014 Jul 22. pii: jbc.M114.580662. Edmunds LR, Sharma L, Kang A, Lu J, Vockley J, Basu S, Uppala R, Goetzman ES, Beck ME, Scott D, Prochownik EV.
A nonapoptotic role for CASP2/caspase 2: Modulation of autophagy. Autophagy. 2014 Jun 1;10(6):1054-70. doi: 10.4161/auto.28528. Tiwari M, Sharma LK, Vanegas D, Callaway DA, Bai Y, Lechleiter JD, Herman B.
Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions. FASEB J. 2012 Dec;26(12):4914-24. Zhang C, Huang VH, Simon M, Sharma LK, Fan W, Haas R, Wallace DC, Bai Y, Huang T.
Comparative bioenergetic study of neuronal and muscle mitochondria during aging. Free Radic Biol Med. 2013 Oct;63:30-40. Li H*, Kumar Sharma L*, Li Y*, Hu P, Idowu A, Liu D, Lu J, Bai Y.(*Joint First Authors)
Tumorigenesis: A Mitochondrial Story. J Carcinogene Mutagene 2012, 3:2 Sharma LK, Milstein AC, Bai Y.
Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. Hum Mol Genet. 2011 Dec 1;20(23):4605-16. Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y.
Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging.Nucleic Acids Res. 2010 Apr;38(6):1913-21. Li Y, Li HZ, Hu P, Deng J, Banoei MM, Sharma LK, Bai Y.
Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals. J Clin Endocrinol Metab. 2010 Jan;95(1):422-9. Chavez AO, Kamath S, Jani R, Sharma LK, Monroy A, Abdul-Ghani MA, Centonze VE, Sathyanarayana P, Coletta DK, Jenkinson CP, Bai Y, Folli F, Defronzo RA, Tripathy D.
Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell Res. 2009 Jul;19(7):802-15. Lu J, Sharma LK, Bai Y.
Mitochondrial respiratory complex I: structure, function and implication in human diseases. Curr Med Chem. 2009;16(10):1266-77. Sharma LK, Lu J, Bai Y.
A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet. 2009 May 1;18(9):1578-89. Park JS*, Sharma LK*, Li H, Xiang R, Holstein D, Wu J, Lechleiter J, Naylor SL, Deng JJ, Lu J, Bai Y.(*Joint First Authors)
Overexpression of WsSGTL1 gene of Withania somnifera enhances salt tolerance, heat tolerance and cold acclimation ability in transgenic Arabidopsis plants. PLoS One. 2013 Apr 30;8(4):e63064. Mishra MK, Chaturvedi P, Singh R, Singh G, Sharma LK, Pandey V, Kumari N, Misra P.
Purification and characterization of a novel glucosyltransferase specific to 27beta-hydroxy steroidal lactones from Withania somnifera and its role in stress responses. Biochim Biophys Acta. 2007 Sep;1774(9):1199-207. Madina BR, Sharma LK, Chaturvedi P, Sangwan RS, Tuli R.
Molecular cloning and characterization of one member of 3beta-hydroxy sterol glucosyltransferase gene family in Withania somnifera. Arch Biochem Biophys. 2007 Apr 1;460(1):48-55. Sharma LK, Madina BR, Chaturvedi P, Sangwan RS, Tuli R.
Purification and physico-kinetic characterization of 3beta-hydroxy specific sterol glucosyltransferase from Withania somnifera (L) and its stress response. Biochim Biophys Acta. 2007 Mar;1774(3):392-402. Madina BR, Sharma LK, Chaturvedi P, Sangwan RS, Tuli R.
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