Personal Information
Muhammad Khan

College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

Muhammad Khan
From 2008 to 2012, Ph.D , China
From 2003 to 2005, M.Sc (Zoology) , Pakistan
Work Experiences
From 3/2013 to to date, Associate Professor , College of Basic Medical Sciences, Dalian Medical University
From 9/2012 to 2/2013, Assistant Professor , Department of Zoology, University of the Punjab, Lahore, Pakistan
Chemical Cancer Biology
Natural Product chemistry
Anticancer Drug Discovery from Medicinal Plants
Targeting Hallmarks of Cancer of Selective killing of Cancer Cells
Towards the use of natural compounds as anti-glioma agents,Scholar’s Press GmbH and Co. KG, Germany,978-3-659-84456-0. Khan M, Ma T
Journal Articles
Killing cancer with platycodin D through multiple mechanisms. J Cell Mol Med. 2016; 20(3), 389-402.KhanM, Maryam A, Zhang H, Mehmood T, Ma T.
Targeting apoptosis and multiple signaling pathways with IcarisideⅡ in cancer cells. Int J Bio Sci., 2015; 11(9): 1100-1112.Khan M, Maryam A, Qazi J.I, Ma T.
Enhancing the activity of anticancer drugs in multidrug resistant tumors by modulating p-glycoprotein through dietary nutraceuticals. Asian Pac J Cancer Prev., 2015;16(16), 6831-6839.Khan M*, Maryam A, Mehmood T, Zhang Y, Ma T
Evodiamine sensitizes U87 glioblastoma cells to TRAIL via Death receptor pathway. Mol Med Rep., 2015;11(1):257-62.Khan M, Bi Y, Qazi J.I, Fan L, Gao H
Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation and mitochondrial dysfunction. BioMed Research International, 2013; doi; M, Li T, Rasul A, Nawazs F, Sun M, Zheng Y and Ma T.
Evodiamine induces apoptosis in pancreatic carcinoma PANC-1cells via NF κB inhibition, Bangl. J. Pharmacol., 2013; 8: 8-14.Khan M, Qazi J.I, Rasul A, Zheng Y and Ma T
Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation and mitochondrial dysfunction, IUBMB Life, 2012;64(9):783-94.Khan M, Yi F, Rasul A, Li T, Wang N, Gao H, Gao R, Ma T.
Pseudolaric acid B induces caspase-dependent and caspase- independent apoptosis in U87 glioblastoma cells, Evid Based Complement Alternat Med., 2012; doi:10. 1155/ 2012/ 957568.Khan M, Zheng B, Yi F, Rasul A, Gu Z, Li T, Gao H, Qazi J.I, Yang H, Ma T.
Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells, Int J Biol Sci., 2012;8(4):533-47.Khan M, Ding C, Rasul A, Yi F, Li T, Gao H, Gao R, Zhong L, Zhang K, Fang X, Ma T.
Jaceosidin induces apoptosis in U87 glioblastoma cells through G2/M phase arrest, Evid Based Complement Alternat Med., 2012; doi: 10.1155/2012/703034.Khan M, Yu B, Rasul A, Al Shawi A, Yi F, Yang H, Ma T.
Increased differentiation capacity of bone marrow-derived mesenchymal stem cells in aquaporin-5 deficiency, Stem Cells Dev. 2012; 1:21(13):2495-507.Yi F, Khan M, Gao H, Hao F, Sun M, Zhong L, Lu C, Feng X, Ma T.
Dracorhodin perchlorate Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis, Apoptosis., 2012; 17(10):1104-19.Rasul A, Chuan D, Li X, Khan M, Yi F, Ali M, Ma T.
Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy, Oncol rep., 2012;27(5):1481-7.Rasul A, Yu B, Zhong L, Khan M, Yang H, Ma T.
Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways, Int J Oncol., 2012;40(4): 1153 -61.Rasul A, Yu B, Khan M, Zhang K, Iqbal F, Ma T, Yang H.
Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Pharmazie, 2013; 68(9): 755-62.Zhou Y, Bi Y, Yang C, Yang J, Jiang Y, Meng F, Yu B, Khan M, Ma T, Yang H.
Vitmin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via mitochondria-related apoptotic pathway. Pharmazie, 2013; 68(6): 442-8.Jiang Y, Yang J, Yang C, Meng F, Zhou Y, Yu B, Khan M, Yang H.
Prevalence of Infarct, villous clump, and alpha-smooth muscle actin expression in basal plate of placenta in severe preeclampsia. Mol Med Rep., 2013; 8(4): 1067-1073.Kong M, Liu L, Yi F, Khan M, Rasul A, Yang F, Ma X, Ma T.
Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase /Akt signaling pathways, Archives of Pharmacal Research., 2013; 36(10):1262-9.Rasul A, Khan M, Yu B, Ali M, Yang J, Yang H, Ma T.
Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone. Sci World J., 2013; 10.1155/2013/248532.Rasul A, Khan M, Ali M, Li J, Li X.
Isoalantolactone inhibits constitutive NF-κB activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction. Oncol rep., 2014;32(4):1585-93.Di W, Khan M, Rasul A, Sun M, Sui Y, Zhong L, Yang L, Zhu Q, Feng L, Ma T.
Four-component electrophilic difunctionalization of olefins using sulfonic acids, cyclic ethers and NBS. Tetrahedron Lett., 2015;56 (42): 5743-5746.Sohail M, Khan M, Zhang Y, Peng C, Chen Q, Zhao Z.K.
Bromophosphoalkoxylation of Olefins with Organic Phosphates, Cyclic Ethers and NBS. Tetrahedron., 2016; 72(5), 658–663.Sohail M, Peng C, Ning S, Zhang Y, Khan M, Zhao Z.K.
Tubeimoside-1 induces G0/G1 phase arrest and oxidative stress mediated-apoptosis in human prostate carcinoma DU145 cells. Acta Pharmacol Sin., 2016; 37(7):950-62.Yang J, Khan M, He Y, Yao M, Li Y, Gao H, Ma T.
Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition and mitochondrial dysfunction. Biofactors., 2016; 43(1):63-72.Mehmood T, Maryam A, Zhang H, Li Y, Khan M*, Ma T*.
Vitamin K4 inhibits proliferation and induces apoptosis in U2OS osteosarcoma cells through mitochondrial dysfunction. Mol Med Rep., 2017;15: 277-284.Di W, Khan M, Gao Y, Cui J, Deqiang W, Feng L, Maryam A, Gao H.
Is oxidative stress in cancer cells a real therapeutic target? Clin Oncol., 2017;2:1211.Khan M*, Ma T
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