Personal Information
Elsayed Abdelkreem

Department of Pediatrics, Sohag University, Nasser, Sohag, Egypt

Elsayed Abdelkreem
From 09/2017 to Present, Diploma of Health Profession Education , Egypt
From 10/2013 to 03/2018, PhD in Pediatrics , Egypt
From 04/2009 to 06/2013, MSc. in Pediatrcs , Egypt
From 09/2001 to 02/2008, MBBCH , Egypt
Work Experiences
From 04/2018 to Present, Lecturer of Pediatrics , Sohag University
From 07/2017 to 03/2018, Assistant Lecturer of Pediatrics , Sohag University
From 07/2015 to 07/2017, Visiting Researcher , Gifu University
From 07/2013 to 07/2015, Assistant Lecturer of Pediatrics , Sohag University
From 04/2012 to 07/2013, Demonstrator of Pediatrics , Sohag University
From 03/2009 to 04/2012, Resident Pediatrician , Sohag University Hospital
From 11/2010 to 04/2012, Features of Cerebral Cortex Malformation In Children , To Characterize the clinical, imaging, and electrophysiological features of children with Cerebral Cortex Malformation
From 01/2015 to 03/2018, Clinical and Molecular Characterization of Beta-ketothiolase Deficiency , To characterize the clinical, biochemical, and molecular features of children with beta-ketothiolase deficiency
From 07/2018 to Present, Characterization and outcome of Egyptian Children with Inherited Metabolic Diseases , To study the clinical, biochemical, and genetic features of Egyptian children with inherited metabolic diseases
Inherited Metabolic Diseases
Pediatric Intensive Care
Pediatric Emergencies
Health Profession Education
Journal Articles
Nakama M, Otsuka H, Ago Y, Sasai H, Abdelkreem E, Aoyama Y, Fukao T (2018) Intronic antisense Alu elements have a negative splicing effect on the inclusion of adjacent downstream exons. Gene 664:84-89. DOI: 10.1016/j.gene.2018.04.064
Sasai H, Aoyama Y, Otsuka H, Abdelkreem E, Naiki Y, Kubota M, Sekine Y, Itoh M, Nakama M, Ohnishi H, Fujiki R, Ohara O, Fukao T (2017) Heterozygous carriers of succinyl-CoA:3-oxoacid CoA transferase deficiency can develop severe ketoacidosis. J Inherit Metab Dis 40(6): 845–852. DOI: 10.1007/s10545-017-0065-z1
Aoyama Y, Sasai H, Abdelkreem E, Otsuka H, Nakama M, Kumar S, Aroor S, Shukla A, Fukao T (2017) A novel mutation (c.121 13T>A) in the polypyrimidine tract of the splice acceptor site of intron 2 causes exon 3 skipping in mitochondrial acetoacetyl-CoA thiolase gene. Mol Med Rep. 15(6): 3879-3884. DOI: 10.3892/mmr.2017.6434
Nguyen KN, Abdelkreem E, Colombo R, Hasegawa Y, Can NT, Bui TP, Le HT, Tran MT, Nguyen HT, Trinh HT, Aoyama Y, Sasai H, Yamaguchi S, Fukao T, Vu DC (2017) Characterization and outcome of 41 patients with beta-ketothiolase deficiency: 10 years' experience of a medical center in northern Vietnam. J Inherit Metab Dis 40(3): 395-401. DOI: 10.1007/s10545-017-0026-6
Sasai H, Aoyama Y, Otsuka H, Abdelkreem E, Nakama M, Hori T, Ohnishi H, Turner L, Fukao T (2017) A single nucleotide substitution T to A in the poly-pyrimidine stretch at splice acceptor site of intron 9 causes exon 10 skipping in ACAT1 gene. Mol Genet Genomic Med 5(2): 177-184. DOI: 10.1002/mgg3.275
Abdelkreema E, Alobaidy H, Aoyama Y, Mahmoud S, Abd El Aal M, Fukao T (2017) Two Libyan siblings with beta-ketothiolase deficiency: A case report and review of literature. Egypt J Med Hum Genet 18(2): 199-203. DOI: 10.1016/j.ejmhg.2016.11.001
Abdelkreem E, Akella RR, Dave U, Sane S, Otsuka H, Sasai H, Aoyama Y, Nakama M, Ohnishi H, Mahmoud S, Abd El Aal M, Fukao T (2017) Clinical and Mutational Characterizations of Ten Indian Patients with Beta-Ketothiolase Deficiency. In: Morava E., Baumgartner M., Patterson M., Rahman S., Zschocke J., Peters V. (eds) JIMD Reports, vol 35. Springer, Berlin, Heidelberg. DOI: 10.1007/8904_2016_26
Otsuka H, Sasai H, Abdelkreem E, Kawamoto N, Kawamoto M, Kamiya T, Tanimoto Y, Kikuchi A, Kure S, Numakura C, Hayasaka K, Fukao T (2016) Effectiveness of Medium-Chain Triglyceride Oil Therapy in Two Japanese Citrin-Deficient Siblings: Evaluation Using Oral Glucose Tolerance Tests. Tohoku J Exp Med. 240(4):323-328. DOI: 10.1620/tjem.240.323
Otsuka H, Sasai H, Nakama M, Aoyama Y, Abdelkreem E, Ohnishi H, Konstantopoulou V, Sass JO, Fukao T (2016) Exon 10 skipping in ACAT1 caused by a novel c.949G>A mutation located at an exonic splice enhancer site. Mol Med Rep. 14(5): 4906-4910. DOI: 10.3892/mmr.2016.5819
Erdol S, Ture M, Yakut T, Saglam H, Sasai H, Abdelkreem E, Otsuka H, Fukao T (2016) A Turkish patient with succinyl-CoA:3-oxoacid CoA transferase deficiency mimicking diabetic ketoacidosis. J Inborn Errors Metab Screen. 4(1): 1-5. DOI: 10.1177/2326409816651281
Abdelkreem E, Otsuka H, Sasai H, Aoyama Y, Hori T, Abd El Aal M, Mahmoud S, Fukao T (2016) Beta-ketothiolase deficiency: Resolving challenges in diagnosis. J Inborn Errors Metab Screen. 4(1): 1-9. DOI: 10.1177/2326409816636644
Sadek AA, Ahmed Sharaf AE, Abdelkreem EM, Abdul Wahed SR (2013) Clinical Features of Cerebral Cortex Malformations in Children: A Study in Upper Egypt. OMICS J Radiology. 2(5): 123. DOI: 10.4172/2167-7964.1000123
Conference Papers
Clinical, biochemical, and molecular features of beta-ketothiolase deficiency: a case series of 23 patients, 4th Scientific Conference of Young Researchers, 17-18 Apr 2018, Sohag, Egypt,
Pediatric emergencies: case scenarios and pitfalls, 1st workshop of Sohag University Hospital PICU, 11 Apr 2018, Sohag Egypt.
Modes and settings of Mechanical Ventilation, Basics of Neonatal Mechanical Ventilation Workshop, 19-21 Jul 2017, Sohag, Egypt.
Clinical and mutational characterizations of 10 Indian patients with beta-ketothiolase deficiency, Conference of Japanese Society of Inherited Metabolic Diseases (JSIMD 58) 27-29 Oct 2016, Tokyo, Japan
Molecular characterization of beta-ketothiolase deficiency in 10 Indians: Discovery of 4 novel mutations in ACAT1 gene, The 13th International Congress of Human Genetics (ICGH), 3-7 Apr 2016, Kyoto, Japan.
Pediatric emergencies; Case presentations, Pediatric Emergencies Workshop. 10-11 Jun 2015, Sohag, Egypt.
Pediatric Basic Life Support, 1st Aid Management Workshop. Medical Education and Development Center, Clinical Skill Lab, 1-9 Feb 2014, Sohag, Egypt.
Invited Talks
Elsayed Abdelkreem, Non-diabetic Ketoacidosis, 2nd Joint Al-Azhar Pediatric Conference, 05-07 Jul 2018, Alexandria, Egypt.
Elsayed Abdelkreem, Metabolism and disorders of ketone bodies, 1st Sohag Conference of Inborn Errors of Metabolism, 26-27 Feb 2018, Sohag Egypt
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