Personal Information
Ashok Kumar

Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh, India

Ashok Kumar
From 06/2001 to 06/2006, PhD , India
Work Experiences
From 06/2006 to 12/2006, Senior Research Fellow , Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
From 12/2006 to 09/2007, Postdoctoral Research Associate , Texas A&M University-HSC, Temple, TX, USA
From 09/2007 to 09/2012, Postdoctoral Fellow , Children's Hospital Oakland Research Institute, Oakland, USA
From 09/2012 , Assistant Professor , All India Institute of Medical Sciences (AIIMS) Bhopal
From 2014 to continued, Involvement of sphingosine-1-phosphate (S1P) signaling in oral cancer patients , Funded by SERB, Department of Science & Technology
Cancer Biology
Sphingolipid Signaling
Book Chapter: Sphingosine-1-Phosphate. In: Encyclopedia of Signaling Molecules. Sangdun Choi (Ed). Springer Publication. 2012, p1771. Kumar A* and Saba JD.
Journal Articles
S1P lyase regulates myogenic differentiation via S1PR-mediated effects on myogenic miRNA expression. FASEB Journal 2013 PMID: 24158395 (In Press). de la Garza-Rodea AS, Baldwin D, Oskouian B, Place Robert, Bandhuvula P, Kumar A, and Saba JD.
Chemopreventive Sphingadienes Downregulate Wnt Signaling in Human Colon Cancer Cells and Intestinal Tissues of ApcMin/+ Mice. Carcinogenesis 2012 Sep;33(9):1726-35. Kumar A, Pandurangan AK, Lu F, Fyrst F, Zhang M, Byun HS, Bittman R, and Saba JD.
Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res. 2012 Sep; 53(9): 1920-31. Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD.
The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochem Bioph Res Commun 2012 Jul 20;424(1):18-21. Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, and Hecht SS.
Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through an S1PR2/STAT3 signaling pathway PLoS One 2012, 7(5) e37218. Loh KC, Leong WI, Carlson ME, Oskouian B, Kumar A, Fyrst F, Zhang M, Proia RL, Hoffman E and Saba JD.
Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. Biomolecules 2013, 3, 351-368. Smith, G.S.; Kumar, A.; Saba, J.D.
Sodium Iodide Symporter, Estrogen Receptor and Progesterone Receptor Expression in Carcinoma Breast - an Immunohistochemical Analysis. Indian J Pathology and Microbiology. 2011, 54 (4) 745-751. Tandon A, Shrivastava A, Kumar A, Prayaga AK, Sundaram C, Godbole MM.
The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cellular Signaling 2011 Jul;23(7):1144-52. Kumar A, Byun HS, Bittman R and Saba JD.
S1P Lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Cell Death & Disease 2011 2, e119. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F and Saba JD.
Lyase to live by: Sphingosine phosphate lyase as a therapeutic target. Expert Opin Ther Targets. 2009 Aug;13(8):1013-25. Kumar A and Saba JD.
Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR). Mol Cell Neurosci. 2009 Mar;40(3):354-64. Sinha RA, Pathak A, Kumar A, Tiwari M, Shrivastava A, Godbole MM.
Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances apoptosis in malignant glioma cells. Carcinogenesis. 2008 Mar;29(3):600-9. Tiwari M, Bajpai VK, Sahasrabuddhe AA, Kumar A, Sinha RA, Behari S, Godbole MM.
Hyperthyroidism induces apoptosis in rat liver through activation of death recepKumar A, Sinha RA, Tiwari M, Singh R, Koji T, Manhas N, Rastogi L, Pal L, Shrivastava A, Sahu RP, Godbole MM.tor-mediated pathways. Journal of Hepatology 2007; 46(5):888-898.
Mechanism of 4-HPR induced apoptosis in glioma cells: Evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress. Carcinogenesis 2006; 27(10):2047-2058. Tiwari M, Kumar A, Sinha RA, Shrivastava A, Balapure AK, Sharma R, Bajpai VK, Mitra K, Babu S, and Godbole MM.
Increased pro-Nerve Growth Factor and p75NTR levels in developing hypothyroid rat cerebral cortex are associated with enhanced apoptosis. Endocrinology 2006; 147(10):4893-4903. Kumar A, Sinha RA, Tiwari M, Pal L, Shrivastava A, Singh R, Kumar K, Gupta SK, and Godbole MM.
Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving mitochondria-mediated pathway. Journal of Biological Chemistry 2006; 281(28): 19762-19771. Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, and Godbole MM
Upadhyay G, Singh R, Kumar A, Kumar S, Kapoor A, Godbole MM. Severe hyperthyroidism induces mitochondria-mediated apoptosis in rat liver. Hepatology 2004; 39(4):1120-1130.
Hypothyroidism alters the expression of Bcl-2 family genes to induce enhanced apoptosis in the developing cerebellum. J Endocrinology 2003 176(1):39-46. Singh R, Upadhyay G, Kumar S, Kapoor A, Kumar A, Tiwari M, Godbole MM.
Strain Characterization of vp1/vp2 gene of Canine Parvovirus of Indian origin. Journal of Applied Animal Research, 2004;25: 56-60. Kumar A, Dharmadheeran JS, Kumar A, Thakral SS.
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