Personal Information
Houkai Li

Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Houkai Li
Educations
From 2002 to 2005, M.S. , China
From 2005 to 2008, PhD , China
Work Experiences
From 2008 to 2011, Postdoc , Institute of nutrition science, Shanghai institute of life sciences, Chinese academy of sciences
From 2011 to 2013, Postdoc , University of North Carolina
From 2013 to present, professor , Shanghai University of Traditional Chinese Medicine
Projects
From 2014 to 2016, Explore Effects of Gut Microbiota on the Lipid-Lowering Efficacy of Simvastatin Metabolomics Based on Metabolomics
From 2014 to 2017, Effects of Gut Microbiota on obesity and Fatty Liver Formation and the Intervention Effect of Chinese Herbs
From 2017 to 2019, Study on Mechanism of Chinese Herbal Medicine in Preventing Obesity
From 2017 to 2020, Study on the Mechanism of Astragalus Polysaccharides in Preventing Obesity Based on the Relationship between Intestinal Flora and Host Energy Metabolism
Speciality
The mechanistic involvement of gut microbiota in metabolic diseases
Exploring novel components for treatment of obesity and nonalcoholic fatty liver disease from TCM
Book
TCM treatment of nonalcoholic fatty liver disease, Science Press
Application of Metabolomics in Precision Medicine, Shanghai Jiaotong University Press
Journal Articles
Junli Ma, Qihang Zhou and Houkai Li*. Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy. Nutrients 2017, 9, 1124; doi:10.3390/nu9101124
Bingbing Li , Xuyun He , Wei Jia* and Houkai Li*, Novel Applications of metabolomics in Personalized Medicine: A Mini-Review. Molecules 2017, 22, 1173; doi:10.3390/molecules22071173.
Xuyun He, Ningning Zheng, Jiaojiao He, Can Liu, Jing Feng, Wei Jia,* and Houkai Li* Gut microbiota modulation attenuated the hypolipidemic effect of simvastatin in high-fat/cholesterol-diet fed mice. Journal of Proteome Research, 2017, , 16 (5), pp 1900–1910
Xueqing Hu, Jiaying Shen, Xueyan Pu, Ningning Zheng, Zhongping Deng, Zean Zhang* and Houkai Li*. Urinary Time- or Dose-Dependent Metabolic Biomarkers of Aristolochic Acid-Induced Nephrotoxicity in Rats. Toxicological Sciences, 2017, 1–10.
Ningning Zheng, Ke Wang, Jiaojiao He, Yunping Qiu, Guoxiang Xie, Mingming Su, Wei Jia, Houkai Li*. Effects of ADMA on gene expression and metabolism in serum-starved LoVo cells. Scientific Reports. 6, 25892; doi: 10.1038/srep25892 (2016).
Xuyun He, Guang Ji, Wei Jia* and Houkai Li* Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics. International Journal of Molecular Sciences, doi:10.3390/ijms17030300 (2016)
Houkai Li*, Jiaojiao He, Wei Jia* The influence of gut microbiota on drug metabolism and toxicity. Expert Opinion on Drug Metabolism & Toxicology. 2016, 12(1):31-40.
Jiaojiao He, Ke Wang, Ningning Zheng, Yunping Qiu, Guoxiang Xie, Mingming Su, Wei Jia, Houkai Li* Metformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration. Scientific Reports. DOI: 10.1038/srep17423, 2015.
Yunping Qiu, Guoxiang Cai, Bingsen Zhou, Dept Of Mo, Dan Li, Aihua Zhao, Guoxiang Xie, Houkai Li, Sanjun Cai, Dong Xie, Changzhi Huang, Weiting Ge, Zhanxiang Zhou,LH Xu,Weiping Jia, Shu Zheng,Yun Yen,Wei Jia. A distinct metabolic signature of human colorectal cancer with prognostic potential. Clinical Cancer Research, 20(8); 2136–46. 2014.
Houkai Li, Wei Jia. Co-metabolism of microbes and host: implications for drug metabolism and drug-induced toxicity. Clinical Pharmacology & Therapeutics, 94(5),574-81, 2013.
Houkai Li, Yalu Zhou, Aihua Zhao, YunpingQiu, GuoxiangXie, Qi Jiang, XiaojiaoZheng, Wei Zhong, Xiuhua Sun, Zhanxiang Zhou, Wei Jia. Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of Fas (APO-1/CD95)/JNK (SAPK) pathway. Cell Death & Disease, 4,e830; doi:10.1038/cddis.2013.345.
Chunxia Wang #, Houkai Li #, Qingshu Meng #, Ying Du, Fei Xiao, Qian Zhang, Junjie Yu, Kai Li, Shanghai Chen, Zhiying Huang, Bin Liu, Feifan Guo ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression. Journal of Cellular and molecular medicine. 18(1):80-90,2014.
Xiaojiao Zheng, Aihua Zhao, Guoxiang Xie, Yi Chi, Linjing Zhao, Houkai Li, Mike Luther, Mingming Su, Jeremy Nicholson, Wei Jia. Melamine-induced renal toxicity is mediated by gut microbiota. Science Translational Medicine, 13(5), 172(ra22), 2013.
Guoxiang Xie, Wei Zhong, Houkai Li, Qiong Li,Yunping Qiu,Wei Jia. Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB journal, 27(9):3583-93, 2013.
Guoxiang Xie, Xin Li, Houkai Li, Wei Jia. Toward personalized nutrition: comprehensive phytoprofiling and metabotyping. Journal of Proteome Research, 12(4), 1547-59, 2013.
Mingmei Zhou, Shidong Wang, Aihua Zhao, Ke Wang, Ziquan Fan, Hongzhou Yang, Wen Liao, Si Bao, Linjing Zhao, Yinan Zhang, Yongqing Yang, Yunping Qiu, Guoxiang Xie, Houkai Li*, Wei Jia*. Transcriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice. Journal of Proteome Research, 11(10),4961-71,2012.
Jie Wei, Guoxiang Xie, Shuyun Ge, Yunping Qiu, Wei Liu, Aiping Lu, Tianlu Chen, Houkai Li, Zengtong Zhou, Wei Jia. Metabolic transformation of DMBA-induced carcinogenesis and inhibitory effect of salvianolic acid b and breviscapine treatment. Journal of Proteome Research, 11(2):1302-16, 2012.
Chun Yao, Nong Tang, Guoxiang Xie, Xiaojiao Zheng, Ping Liu,Lei Fu, Wu Xie, Fan Yao, Houkai Li, and Wei Jia. Management of Hepatic Encephalopathy by Traditional ChineseMedicine. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2012/835686, 2012.
Houkai Li, Qingshu Meng, Fei Xiao, Shanghai Chen, Bing Liu, Feifan Guo. ATF4 deficiency protects mice from high-carbohydrate diet-induced liver steatosis. Biochemical Journal, 438(2), 283–89,2011.
Fei Xiao, Zhiying Huang, Houkai Li, Junjie Yu, Chunxia Wang, Shanghai Chen, Qingshu Meng, Ying Cheng, Feifan Guo Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes, 60(3), 746-56, 2011.
Qian Zhang, Houkai Li, Feifan Guo. Amygdala, an important regulator for food intake. Frontiers of biology, 6(1),82-85,2011.
Ying Cheng, Qingshu Meng, Chunxia Wang, Houkai Li, Zhiying Huang, Shanghai Chen, Fei Xiao, Feifan Guo. Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes, 59(1),17-25,2010.
Zuoquan Xie#, Houkai Li#, Ke Wang, Jingchao Lin, Qi Wang, Guoping Zhao, Wei Jia, Qinghua Zhang. Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. Metabolism, 59(4),554-60,2010.
Guoxiang Xie, Xiaojiao Zheng, Xin Qi, Yu Cao, Yi Chi, Mingming Su, Yan Ni, Yunping Qiu, Yumin Liu, Houkai Li, Aihua Zhao, Wei Jia. Metabonomic Evaluation of Melamine-Induced Acute Renal Toxicity in Rats. Journal of Proteome Research, 9(1),125–33,2010.
Houkai Li, Mingmei Zhou, Aihua Zhao, Wei Jia. Traditional Chinese medicine: balancing the gut ecosystem. Phytotherapy research, 23(9),1332-35,2009.
Houkai Li, Min Dai, Wei Jia. Paeonol attenuates high-fat-diet-induced atherosclerosis in rabbits by anti-inflammatory activity. Planta Medica, 75(1),7-11,2009.
Houkai Li#, Zuoquan Xie#, Jingchao Lin, Huaiguang Song, Qi Wang, Ke Wang, Mingming Su, Yunping Qiu, Tie Zhao, Kai Song, Xiaoyan Wang, Mingmei Zhou, Ping Liu, Guoping Zhao, Qinghua Zhang, and Wei Jia . Transcriptomic and Metabonomic Profiling of Obesity-Prone and Obesity-Resistant Rats under High Fat Diet. Journal of Proteome Research, 7(11), 4775-83,2008.
Wei Jia, Houkai Li, Liping Zhao and Jeremy K. Nicholson. Gut microbiota: a potential new territory for drug targeting. Nature Reviews Drug Discovery, 7(2),123-29,2008.
Qing Shen, Xin Li, Yunping Qiu, Mingming Su, Yumin Liu, Houkai Li, Xiaoyan Wang, Xiangyu Zou, Chonghuai Yan, Lan Yu, Sheng Li, Chunling Wan, Lin He,, and Wei Jia. Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats. Journal of Proteome Research, 7(5), 2151–57, 2008.
Qing Shen, Xin Li, Yunping Qiu, Mingming Su, Yumin Liu, Houkai Li, Xiaoyan Wang, Xiangyu Zou, Chonghuai Yan, Lan Yu, Sheng Li, Chunling Wan, Lin He,, and Wei Jia. Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats. Journal of Proteome Research, 7(5), 2151–57, 2008.
Houkai Li#, Yan Ni#, Mingming Su#, Yunping Qiu#, Mingmei Zhou#, Mingfeng Qiu, Aihua Zhao, Liping Zhao, Wei Jia. Pharmaco-metabonomic Phenotyping Reveals Different Responses to Xenobiotic Intervention in Rats. Journal of Proteome Research, 6(4),1364-70, 2007.
Guoxiang Xie, Mingming Su, Peng Li, Xue Gu, Chao Yan, Yunping Qiu, Houkai Li, Wei Jia. Analysis of urinary metabolites for metabolomic study by pressurized CEC. Electrophoresis, 28(23), 4459–4468, 2007.
Invited Talks
4th International Conference and Exhibition on Metabolomics and Systems Biology in Philadelphia, USA, April 27-29, 2015.
6th International Conference and Exhibition on Metabolomics” in Osaka, Japan, May 16-18, 2016.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186